Publikationen

2017

Brandes S, Dietrich S, Hünniger K, Kurzai O, Figge MT (2017) Migration and Interaction Tracking for Quantitative Analysis of Phagocyte-Pathogen Confrontation Assays. Medical Image Analysis 36, 172-183. 

Cunha C, Gonçalves SM, Duarte-Oliveira C, Leite L, Lagrou K, Marques A, Lupiañez CB, Mesquita I, Gaifem J, Barbosa AM, Pinho Vaz C, Branca R, Campilho F, Freitas F, Ligeiro D, Lass-Flörl C, Löffler J, Jurado M, Saraiva M, Kurzai O, Rodrigues F, Castro AG, Silvestre R, Sainz J, Maertens JA, Torrado E, Jacobsen ID, Lacerda JF, Campos A, Carvalho A (2017) IL-10 overexpression predisposes to invasive aspergillosis by suppressing antifungal immunity. J Allergy Clin Immunol.

Dix A, Czakai K, Leonhardt I, Schäferhoff K, Bonin M, Einsele H, Guthke R, Kurzai O, Löffler J, Linde J (2017) Specific and novel microRNAs are regulated as response to fungal infection in human dendritic cells Front. Microbiol. 8. 

Fischer M, Müller JP, Spies-Weisshart B, Gräfe C, Kurzai O, Hünniger K, Hochhaus A, Scholl S, Schnetzke U (2017) Isoform localization of Dectin-1 regulates the signaling quality of anti-fungal immunity. Eur J Immunol 47(5), 848-859. 

Martin R, Pohlers S, Mühlschlegel FA, Kurzai O (2017) CO2 sensing in fungi: at the heart of metabolic signaling. Curr Genet. 

Pohlers S, Martin R, Krüger T, Hellwig D, Hänel F, Kniemeyer O, Saluz HP, Van Dijck, Ernst JF, Brakhage A, Mühlschlegel FA, Kurzai O (2017) Lipid signaling via Pkh1/2 regulates fungal CO2 sensing through the kinase Sch9 mBio 8(1), e02211-16. 

Polke M, Leonhardt I, Kurzai O, Jacobsen ID (2017) Farnesol signalling in Candida albicans - more than just communication. Crit Rev Microbiol [Epub ahead of print]

Polke M, Sprenger M, Scherlach K, Albán-Proaño MC, Martin R, Hertweck C, Hube B, Jacobsen ID (2017) A functional link between hyphal maintenance and quorum sensing in Candida albicans. Mol Microbiol 103(4), 595-617. 

Weber M, Schaer J, Walther G, Kaerger K, Steinmann J, Rath PM, Spiess B, Buchheidt D, Hamprecht A, Kurzai O (2017) FunResDB-A web resource for genotypic susceptibility testing of Aspergillus fumigatus. Med Mycol.

2016

Beitzen-Heineke A, Bouzani M, Schmitt AL, Kurzai O, Hünniger K, Einsele H, Loeffler J (2016) Human Invariant Natural Killer T cells possess immune-modulating functions during Aspergillus infection. Med Mycol 54(2), 169-176.

Blaurock N, Schmerler D, Hünniger K, Kurzai O, Ludewig K, Baier M, Brunkhorst FM, Imhof D, Kiehntopf M (2016) C-Terminal Alpha-1 Antitrypsin Peptide: A New Sepsis Biomarker with Immunomodulatory Function. Mediators Inflamm 2016, 6129437.

Böhringer M, Pohlers S, Schulze S, Albrecht-Eckardt D, Piegsa J, Weber M, Martin R, Hünniger K, Linde J, Guthke R, Kurzai O (2016) Candida albicans infection leads to barrier breakdown and a MAPK/NF-κB mediated stress response in the intestinal epithelial cell line C2BBe1. Cellular Microbiology 18(7), 889-904.

Brandes S, Dietrich S, Hünniger K, Kurzai O, Figge MT (2016) Migration and Interaction Tracking for Quantitative Analysis of Phagocyte-Pathogen Confrontation Assays. Medical Image Analysis 36, 172-183.

Czakai K, Leonhardt I, Dix A, Bonin M, Linde J, Einsele H, Kurzai O, Löffler J (2016) Krüppel-like Factor 4 modulates interleukin-6 release in human dendritic cells after in vitro stimulation with Aspergillus fumigatus and Candida albicans Sci Rep 6, 27990.

Fliesser M, Wallstein M, Kurzai O, Einsele H, Löffler J (2016) Hypoxia attenuates anti-Aspergillus fumigatus immune responses initiated by human dendritic cells. Mycoses 59(8), 503-508.

Hellwig D, Voigt J, Bouzani M, Löffler J, Albrecht-Eckardt D, Weber M, Brunke S, Martin R, Kurzai O, Hünniger K (2016) Candida albicans induces metabolic reprogramming in human NK cells and responds to perforin with a Zinc depletion response. Front Microbiol 7, 750.

Hube B, Kurzai O (2016) Text book chapter in: Clinical Mycology at Oxford University Press. Chapter: Candida. In: Clinical Mycology Oxford University Press.

Janhsen WK, Arnold C, Hentschel J, Lehmann T, Pfister W, Baier M, Böer K, Hünniger K, Kurzai O, Hipler UC, Mainz JG (2016) Colonization of CF patients' upper airways with S. aureus contributes more decisively to upper airway inflammation than P. aeruginosa. Med Microbiol Immunol 205(5), 485-500.

Moyes DL*, Wilson D*, Richardson JP*, Mogavero S*, Tang SX, Wernecke J, Höfs S, Gratacap RL, Robbins J, Runglall M, Murciano C, Blagojevic M, Thavaraj S, Förster TM, Hebecker B, Kasper L, Vizcay G, Iancu SI, Kichik N, Häder A, Kurzai O, Luo T, Krüger T, Kniemeyer O, Cota E, Bader O, Wheeler RT, Gutsmann T, Hube B, Naglik JR (2016) Candidalysin is a fungal peptide toxin critical for mucosal infection. Nature 532(7597), 64-68.

Scherag A, Schöneweck F, Kesselmeier M, Taudien S, Platzer M, Felder M, Sponholz C, Rautanen A, Hill AV, Hinds CJ, Hossain H, Suttorp N, Kurzai O, Slevogt H, Giamarellos-Bourboulis EJ, Armaganidis A, Trips E, Scholz M, Brunkhorst FM (2016) Genetic Factors of the Disease Course after Sepsis: A Genome-Wide Study for 28Day Mortality. EBioMedicine 12, 239-246.

Taudien S, Lausser L, Giamarellos-Bourboulis EJ, Sponholz C, Schöneweck F, Felder M, Schirra LR, Schmid F, Gogos C, Groth S, Petersen BS, Franke A, Lieb W, Huse K, Zipfel PF, Kurzai O, Moepps B, Gierschik P, Bauer M, Scherag A, Kestler HA, Platzer M (2016) Genetic Factors of the Disease Course After Sepsis: Rare Deleterious Variants Are Predictive. EBioMedicine 12, 227-238.

2015

Brandes S, Mokhtari Z, Essig F, Hünniger K, Kurzai O, Figge MT (2015) Automated segmentation and tracking of non-rigid objects in time-lapse microscopy videos of polymorphonuclear neutrophils. Medical Image Analysis 20(1), 34-51.

Dix A, Hünniger K, Weber M, Guthke R, Kurzai O, Linde J (2015) Biomarker-based classification of bacterial and fungal whole-blood infections in a genome-wide expression study. Front Microbiol 6, 171.

Duggan S, Essig F, Hünniger K, Mokhtari Z, Bauer L, Lehnert T, Brandes S, Häder A, Jacobsen ID, Martin R, Figge MT, Kurzai O (2015) Neutrophil activation by Candida glabrata but not Candida albicans promotes fungal uptake by monocytes. Cell Microbiol 17(9), 1259-1276.

Duggan S, Leonhardt I, Hünniger K, Kurzai O (2015) Host response to Candida albicans bloodstream infection and sepsis. Virulence, 1-11. (Review)

Essig F, Hünniger K, Dietrich S, Figge MT, Kurzai O (2015) Human neutrophils dump Candida glabrata after intracellular killing. Fungal Genetics and Biology 84, 37-40.

Fliesser M, Morton CO, Bonin M, Ebel F, Hünniger K, Kurzai O, Einsele H, Löffler J (2015) Hypoxia-inducible factor 1α modulates metabolic activity and cytokine release in anti-Aspergillus fumigatus immune responses initiated by human dendritic cells. Int J Med Microbiol 305(8):865-73

Hünniger K, Bieber K, Martin R, Lehnert T, Figge MT, Löffler J, Guo R, Riedemann N, Kurzai O (2015) A second stimulus required for enhanced antifungal activity of human neutrophils in blood is provided by anaphylatoxin C5a. The Journal of Immunology 194(3), 1199-1210.

Huyke J, Martin R, Walther G, Weber M, Kaerger K, Bougnoux ME, Elias J, Kurzai O (2015) Candida albicans bloodstream isolates in a German university hospital are genetically heterogenous and susceptible to commonly used antifungals. Int J Med Microbiol 305(7), 742-747.

Lehnert T*, Timme S*, Pollmächer J, Hünniger K, Kurzai O, Figge MT (2015) Bottom-up modeling approach for the quantitative estimation of parameters in pathogen-host interactions. Frontiers in Microbiology 6(608), *authors contributed equally.

Leonhardt I, Spielberg S, Weber M, Albrecht-Eckardt D, Bläss M, Claus R, Barz D, Scherlach K, Hertweck C, Löffler J, Hünniger K, Kurzai O (2015) The fungal quorum-sensing molecule farnesol activates innate immune cells but suppresses cellular adaptive immunity. MBio 6(2), e00143.

Linde J, Duggan S, Weber M, Horn F, Sieber P, Hellwig D, Riege K, Marz M, Martin R, Guthke R, Kurzai O (2015) Defining the transcriptomic landscape of Candida glabrata by RNA-Seq. Nucleic Acids Res 43(3), 1392-1406.

2014

Cunha C, Aversa F, Lacerda JF, Busca A, Kurzai O, Grube M, Löffler J, Maertens JA, Bell AS, Inforzato A, Barbati E, Almeida B, Santos e Sousa P, Barbui A, Potenza L, Caira M, Rodrigues F, Salvatori G, Pagano L, Luppi M, Mantovani A, Velardi A, Romani L, Carvalho A (2014) Genetic PTX3 deficiency and aspergillosis in stem-cell transplantation. N Engl J Med 370(5), 421-432.

Cunha C, Kurzai O, Carvalho A (2014) PTX3 deficiency and aspergillosis. N Engl J Med 370(17), 1666-1667.

Cunha C, Kurzai O, Löffler J, Aversa F, Romani L, Carvalho A (2014) Neutrophil Responses to Aspergillosis: New Roles for Old Players. Mycopathologia 178(5-6):387-93.

Das Gupta M, Fliesser M, Springer J, Breitschopf T, Schlossnagel H, Schmitt AL, Kurzai O, Hünniger K, Einsele H, Löffler J (2014) Aspergillus fumigatus induces microRNA-132 in human monocytes and dendritic cells. Int J Med Microbiol 304(5-6), 592-596.

Ekaney ML, Otto GP, Sossdorf M, Sponholz C, Boehringer M, Loesche W, Rittirsch D, Wilharm A, Kurzai O, Bauer M, Claus RA (2014) Impact of plasma histones in human sepsis and their contribution to cellular injury and inflammation. Crit Care 18(5), 543.

Hentschel J, Müller U, Doht F, Fischer N, Böer K, Sonnemann J, Hipler C, Hünniger K, Kurzai O, Markert UR, Mainz JG (2014) Influences of nasal lavage collection-, processing- and storage methods on inflammatory markers--evaluation of a method for non-invasive sampling of epithelial lining fluid in cystic fibrosis and other respiratory diseases. J Immunol Methods 404, 41-51.

Hünniger K*, Lehnert T*, Bieber K, Martin R, Figge MT⁺, Kurzai O⁺ (2014) A virtual infection model quantifies innate effector mechanisms and Candida albicans immune escape in human blood. PLoS Comput Biol 10(2), e1003479, */⁺authors contributed equally.

Jacobsen ID, Lüttich A, Kurzai O, Hube B, Brock M (2014) In vivo imaging of disseminated murine Candida albicans infection reveals unexpected host sites of fungal persistence during antifungal therapy. J Antimicrob Chemother 69(10), 2785-2796.

Lother J, Breitschopf T, Krappmann S, Morton CO, Bouzani M, Kurzai O, Gunzer M, Hasenberg M, Einsele H, Loeffler J (2014) Human dendritic cell subsets display distinct interactions with the pathogenic mould Aspergillus fumigatus. Int J Med Microbiol 304(8):1160-8.

Miramón P, Dunker C, Kasper L, Jacobsen ID, Barz D, Kurzai O, Hube B (2014) A family of glutathione peroxidases contributes to oxidative stress resistance in Candida albicans. Med Mycol 52(3), 223-239.

Quintin J, Voigt J, van der Voort R, Jacobsen ID, Verschueren I, Hube B, Giamarellos-Bourboulis EJ, van der Meer JW, Joosten LA, Kurzai O, Netea MG (2014) Differential role of NK cells against Candida albicans infection in immunocompetent or immunocompromised mice. Eur J Immunol 44(8), 2405-2414.

Voigt J, Hünniger K, Bouzani M, Jacobsen ID, Barz D, Hube B, Löffler J, Kurzai O (2014) Human natural killer cells acting as phagocytes against Candida albicans and mounting an inflammatory response that modulates neutrophil antifungal activity. J Infect Dis 209(4), 616-626.

Wartenberg A, Linde J, Martin R, Schreiner M, Horn F, Jacobsen ID, Jenull S, Wolf T, Kuchler K, Guthke R, Kurzai O, Forche A, d'Enfert C, Brunke S, Hube B (2014) Microevolution of Candida albicans in macrophages restores filamentation in a nonfilamentous mutant. PLoS Genet 10(12), e1004824.

Vorher

Cottier F, Leewattanapasuk W, Kemp LR, Murphy M, Supuran CT, Kurzai O, Mühlschlegel FA (2013) Carbonic anhydrase regulation and CO(2) sensing in the fungal pathogen Candida glabrata involves a novel Rca1p ortholog. Bioorg Med Chem 21(6), 1549-1554.

Luo S, Skerka C, Kurzai O, Zipfel PF (2013) Complement and innate immune evasion strategies of the human pathogenic fungus Candida albicans. Mol Immunol 56(3), 161-169.

Martin R, Albrecht-Eckardt D, Brunke S, Hube B, Hünniger K, Kurzai O (2013) A core filamentation response network in Candida albicans is restricted to eight genes. PLoS One 8(3), e58613.

Palige K, Linde J, Martin R, Böttcher B, Citiulo F, Sullivan DJ, Weber J, Staib C, Rupp S, Hube B, Morschhäuser J, Staib P (2013) Global transcriptome sequencing identifies chlamydospore specific markers in Candida albicans and Candida dubliniensis. PLoS One 8(4), e61940.

Bauer R, Mezger M, Blockhaus C, Schmitt AL, Kurzai O, Einsele H, Loeffler J (2012) 40-O -[2-Hydroxyethyl]rapamycin modulates human dendritic cell function during exposure to Aspergillus fumigatus. J Basic Microbiol 52(3), 269-276.

Cottier F, Raymond M, Kurzai O, Bolstad M, Leewattanapasuk W, Jiménez-López C, Lorenz MC, Sanglard D, Váchová L, Pavelka N, Palková Z, Mühlschlegel FA (2012) The bZIP transcription factor Rca1p is a central regulator of a novel CO₂ sensing pathway in yeast. PLoS Pathog 8(1), e1002485-e1002485.

Escalante-Pérez M, Jaborsky M, Reinders J, Kurzai O, Hedrich R, Ache P (2012) Poplar extrafloral nectar is protected against plant and human pathogenic fungus. Mol Plant 5(5), 1157-1159.

Heddergott C, Bruns S, Nietzsche S, Leonhardt I, Kurzai O, Kniemeyer O, Brakhage AA (2012) The Arthroderma benhamiae hydrophobin HypA mediates hydrophobicity and influences recognition by human immune effector cells. Eukaryot Cell 11(5), 673-682.

Kurzai O, Gow N (2012) A case for case reports-And a new publishing platform for clinical mycology. Med Mycol Case Rep 1(1), 17-18.

Miramón P, Dunker C, Windecker H, Bohovych IM, Brown AJ, Kurzai O, Hube B (2012) Cellular responses of Candida albicans to phagocytosis and the extracellular activities of neutrophils are critical to counteract carbohydrate starvation, oxidative and nitrosative stress. PLoS One 7(12), e52850-e52850.

Bouzani M, Ok M, McCormick A, Ebel F, Kurzai O, Morton CO, Einsele H, Loeffler J (2011) Human NK cells display important antifungal activity against Aspergillus fumigatus, which is directly mediated by IFN-γ release. J Immunol 187(3), 1369-1376.

Hellwig D, Emmerth S, Ulbricht T, Döring V, Hoischen C, Martin R, Samora CP, McAinsh AD, Carroll CW, Straight AF, Meraldi P, Diekmann S (2011) Dynamics of CENP-N kinetochore binding during the cell cycle. J Cell Sci 124(Pt 22), 3871-3883.

Kapp M, Schargus M, Deuchert T, Springer J, Wendel F, Loeffler J, Grigoleit GU, Kurzai O, Heinz W, Einsele H, Stuhler G (2011) Endophthalmitis as primary clinical manifestation of fatal fusariosis in an allogeneic stem cell recipient. Transpl Infect Dis 13(4), 374-379.

Kerstan A, Wendel AM, Kurzai O, Bröcker EB, Kolb-Mäurer A (2011) Ulcerating nodules on the right arm after hunting muskrats. J Dtsch Dermatol Ges 9(6), 487-489.

Martin R, Moran GP, Jacobsen ID, Heyken A, Domey J, Sullivan DJ, Kurzai O, Hube B (2011) The Candida albicans-specific gene EED1 encodes a key regulator of hyphal extension. PLoS One 6(4), e18394.

Martin R, Wächtler B, Schaller M, Wilson D, Hube B (2011) Host-pathogen interactions and virulence-associated genes during Candida albicans oral infections. Int J Med Microbiol 301(5), 417-422. (Review)

Morton CO, Clemons KV, Springer J, Mueller JG, Rogers TR, Stevens DA, Kurzai O, Einsele H, Loeffler J (2011) Real-time PCR and quantitative culture for monitoring of experimental Aspergillus fumigatus intracranial infection in neutropenic mice. J Med Microbiol 60(Pt 7), 913-919.

Morton CO, Varga JJ, Hornbach A, Mezger M, Sennefelder H, Kneitz S, Kurzai O, Krappmann S, Einsele H, Nierman WC, Rogers TR, Loeffler J (2011) The temporal dynamics of differential gene expression in Aspergillus fumigatus interacting with human immature dendritic cells in vitro. PLoS One 6(1), e16016-e16016.

Nägele V, Heesemann J, Schielke S, Jiménez-Soto LF, Kurzai O, Ackermann N (2011) Neisseria meningitidis adhesin NadA targets beta1 integrins: functional similarity to Yersinia invasin. J Biol Chem 286(23), 20536-20546.

Schielke S, Spatz C, Schwarz RF, Joseph B, Schoen C, Schulz SM, Hubert K, Frosch M, Schubert-Unkmeir A, Kurzai O (2011) Characterization of FarR as a highly specialized, growth phase-dependent transcriptional regulator in Neisseria meningitidis. Int J Med Microbiol 301(4), 325-333.

Springer J, Loeffler J, Heinz W, Schlossnagel H, Lehmann M, Morton O, Rogers TR, Schmitt C, Frosch M, Einsele H, Kurzai O (2011) Pathogen-specific DNA enrichment does not increase sensitivity of PCR for diagnosis of invasive aspergillosis in neutropenic patients. J Clin Microbiol 49(4), 1267-1273.

Hornbach A, Heyken A, Schild L, Hube B, Löffler J, Kurzai O (2009) The glycosylphosphatidylinositol-anchored protease Sap9 modulates the interaction of Candida albicans with human neutrophils. Infect Immun 77(12), 5216-5224.

Wilson D, Thewes S, Zakikhany K, Fradin C, Albrecht A, Almeida R, Brunke S, Grosse K, Martin R, Mayer F, Leonhardt I, Schild L, Seider K, Skibbe M, Slesiona S, Waechtler B, Jacobsen I, Hube B (2009) Identifying infection-associated genes of Candida albicans in the postgenomic era. FEMS Yeast Res 9(5), 688-700. (Review)

Wozniok I, Hornbach A, Schmitt C, Frosch M, Einsele H, Hube B, Löffler J, Kurzai O (2008) Induction of ERK-kinase signalling triggers morphotype-specific killing of Candida albicans filaments by human neutrophils. Cell Microbiol 10(3), 807-820.

Zakikhany K, Thewes S, Wilson D, Martin R, Albrecht A, Hube B (2008) From attachment to invasion: infection associated genes of Candida albicans. Nihon Ishinkin Gakkai Zasshi 49(4), 245-251.

Lessing F, Kniemeyer O, Wozniok I, Loeffler J, Kurzai O, Haertl A, Brakhage AA (2007) The Aspergillus fumigatus transcriptional regulator AfYap1 represents the major regulator for defense against reactive oxygen intermediates but is dispensable for pathogenicity in an intranasal mouse infection model. Eukaryot Cell 6(12), 2290-2302.