Hülsmann J, Lindemann H, Wegener J, Kühne M, Godmann M, Koschella A, Coldewey SM, Heinze T, Heinzel T (2023) Dually Modified Cellulose as a Non-Viral Vector for the Delivery and Uptake of HDAC3 siRNA. Pharmaceutics 2023 Nov 23;15(12):2659. doi: 10.3390/pharmaceutics15122659. Paper

Neu C, Wissuwa B, Thiemermann C, Coldewey SM (2023) Cardiovascular impairment in Shiga-toxin-2-induced experimental hemolytic-uremic syndrome: a pilot study. Front Immunol. 2023 Sep 22:14:1252818. doi: 10.3389/fimmu.2023.1252818. eCollection 2023. Paper

Verra C, Mohammad S, Ferreira Alves G, Porchietto E, Coldewey SM, Collino M, Thiemermann C (2023) Baricitinib protects mice from sepsis-induced cardiac dysfunction and multiple-organ failure. Front. Immunol., 12 September 2023, Sec. Inflammation,Volume 14 - 2023. Paper

Patel NM, Collotta D, Aimaretti E, Ferreira Alves G, Kröller S, Coldewey SM, Collino M, Thiemermann C (2023) Inhibition of the JAK/STAT Pathway With Baricitinib Reduces the Multiple Organ Dysfunction Caused by Hemorrhagic Shock in Rats. Ann Surg. 2023 Jul 1;278(1):e137-e146. doi: 10.1097/SLA.0000000000005571. Paper

Relja B, Coldewey SM, Ghezzi P, Martin L, Thiemermann C (2023) Editorial: Community series in translational insights into mechanisms and therapy of organ dysfunction in sepsis and trauma, volume II. Front Immunol. 2023 May 25;14:1215888. doi: 10.3389/fimmu.2023.1215888. Paper

Mandal S, Tannert A, Ebert C, Guliev RR, Ozegowski Y, Carvalho L, Wildemann B, Eiserloh S, Coldewey SM, Löffler B, Bastião Silva L, Hoerr V, Tuchscherr L, Neugebauer U (2023) Insights into S. aureus-Induced Bone Deformation in a Mouse Model of Chronic Osteomyelitis Using Fluorescence and Raman Imaging. Int. J. Mol. Sci. 2023, 24, 9762. Paper

Chung HY, Wickel J, Hahn N, Mein N, Schwarzbrunn M, Koch P, Ceanga M, Haselmann H, Baade-Büttner C, von Stackelberg N, Hempel N, Schmidl L, Groth M, Andreas N, Götze J, Coldewey SM, Bauer M, Mawrin C, Dargvainiene J, Leypoldt F, Steinke S, Wang ZQ, Hust M, Geis C. (2023) Microglia mediate neurocognitive deficits by eliminating C1q-tagged synapses in sepsis-associated encephalopathy. Sci Adv. 2023 May 26;9(21):eabq7806. doi: 10.1126/sciadv.abq7806. Epub 2023 May 26. Paper

Patel NM, Oliveira FRMB, Ramos HP, Aimaretti E, Alves GF, Coldewey SM, Collino M, Sordi R, Thiemermann C (2023) Inhibition of Bruton's Tyrosine Kinase Activity Attenuates Hemorrhagic Shock-Induced Multiple Organ Dysfunction in Rats. Ann Surg. 2023 Mar 1;277(3):e624-e633. doi: 10.1097/SLA.0000000000005357. Epub 2021 Dec 27. PMID: 35129479, Paper

Kröller S, Wissuwa B, Dennhardt S, Krieg N, Thiemermann C, Daniel C, Amann K, Gunzer F, Coldewey SM (2023) Bruton's tyrosine kinase inhibition attenuates disease progression by reducing renal immune cell invasion in mice with hemolytic-uremic syndrome. Front Immunol. 2023 Feb 23;14:1105181. doi: 10.3389/fimmu.2023.1105181. eCollection 2023. PMID: 36911665, Paper


Bigge R, Bunk B, Rudolph WW, Gunzer F, Coldewey SM, Riedel T, Schröttner P (2022) Comparative Study of Different Diagnostic Routine Methods for the Identification of Acinetobacter radioresistens. Microorganisms 10 (9), 1767, Paper

Dennhardt S, Pirschel W, Wissuwa B, Imhof D, Daniel C, Kielstein JT, Hennig-Pauka I, Amann K,  Gunzer F, Coldewey SM (2022) Targeting the Innate Repair Receptor Axis via Erythropoietin or Pyroglutamate Helix B Surface Peptide attenuates Hemolytic-Uremic Syndrome in Mice. Front Immunol., Sec. Inflammation, Paper

Patel NM, Collotta D, Aimaretti E, Ferreira Alves G, Kröller S, Coldewey SM, Collino M, Thiemermann C (2022) Inhibition of the JAK/STAT Pathway with Baricitinib Reduces the Multiple Organ Dysfunction Caused by Hemorrhagic Shock in Rats. Ann Surg., doi: 10.1097/SLA.0000000000005571, Paper

Coldewey SM, Neu C, Bloos F, Baumbach P, Schumacher U, Bauer M, Reuken P, Stallmach A (2022) Infliximab in the treatment of patients with severe COVID-19 (INFLIXCOVID): protocol for a randomised, controlled, multicentre, open label phase II clinical study. Trials 23(1):737. doi: 10.1186/s13063-022-06566-5, Paper

Kopf A, Bunk B, Coldewey SM, Gunzer F, Riedel T, Schröttner P (2022) Comparative Genomic Analysis of the Human Pathogen Wohlfahrtiimonas Chitiniclastica Provides Insight Into the Identification of Antimicrobial Resistance Genotypes and Potential Virulence Traits. Front Cell Infect Microbiol, Volume 12, Article 912427, doi: 10.3389/fcimb.2022.912427, Paper

Herminghaus A, Kozlov AV, Szabó A, Hantos Z, Gylstorff S, Kuebart A, Aghapour M, Wissuwa B, Walles T, Walles H, Coldewey SM, Relja B (2022) A barrier to defend - Models of pulmonary barrier to study acute inflammatory diseases, Front Immunol, Volume 13, Article 895100, doi: 10.3389/fimmu.2022.895100, Paper

Neu C, Baumbach P, Scherag A, Kortgen A, Götze J, Coldewey SM (2022) Identification of cardiovascular and molecular prognostic factors for the morbidity and mortality inCOVID-19-sepsis (ICROVID): protocol for a prospective multi-centre cohort study. PLoS One 17(6):e0269247. doi: 10.1371/journal.pone.0269247, Paper

Neu C, Skitek K, Kissler H, Baumbach P, Settmacher U, Esper Treml R, Coldewey SM (2022) Body composition, mitochondrial oxygen metabolism and metabolome of patients with obesity before and after bariatric surgery (COMMITMENT): protocol for a monocentric prospective cohort study. BMJ Open 12:e062592. doi:10.1136/bmjopen-2022-062592, Paper

Bigalke A, Neu C, Esper Treml R, Coldewey SM, Kiehntopf M (2022) Fragments of alpha-1-antitrypsin in patients with severe COVID-19 and bacterial pulmonary sepsis. Clin Chem Lab Med, doi: 10.1515/cclm-2022-0361, Paper

Pirschel W, Mestekemper AN, Wissuwa B, Krieg N, Kröller S, Daniel C, Gunzer F, Tolosano E, Bauer M, Amann K, Heinemann SH, Coldewey SM (2022) Divergent roles of haptoglobin and hemopexin deficiency for disease progression of Shiga-toxin-induced hemolytic-uremic syndrome in mice. Kidney Int. S0085-2538(22)00016-3, doi: 10.1016/j.kint.2021.12.024. Paper

Metzing UB, von Loeffelholz C, Steidl R, Romeike B, Winkler R, Rauchfuß F, Settmacher U, Stoppe C, Coldewey SM, Weinmann C, Weickert MO, Claus RA, Birkenfeld AL, Kosan C, Horn P (2022) Endoplasmic reticulum stress and the unfolded protein response in skeletal muscle of subjects suffering from peritoneal Sepsis. Sci Rep. 12(1):504, doi: 10.1038/s41598-021-04517-9, Paper


von Loeffelholz C, Roth J, Coldewey SM, Birkenfeld AL (2021) The Role of Physical Activity in Nonalcoholic and Metabolic Dysfunction Associated Fatty Liver Disease. Biomedicines 9(12):1853. doi: 10.3390/biomedicines9121853, Paper

Winkler MS, Claus RA, Schilder M, Pöhlmann S, Coldewey SM, Grundmann J, Fricke T, Moerer O, Meissner K, Bauer M, Hofmann-Winkler H, Gräler M (2021) Erythrocytes increase endogenous sphingosine 1-phosphate levels as an adaptive response to SARS-CoV-2 infection. Clin Sci (Lond). 135(24):2781-2791. doi: 10.1042/CS20210666, Paper

Kopf A, Bunk B, Coldewey SM, Gunzer F, Riedel T, Schröttner P (2021) Identification and antibiotic profiling of Wohlfahrtiimonas chitiniclastica, an underestimated human pathogen. Front Microbiol. 12:712775. doi: 10.3389/fmicb.2021.712775, Paper

von Loeffelholz C, Coldewey SM, Birkenfeld AL (2021) A Narrative Review on the Role of AMPK on De Novo Lipogenesis in Non-Alcoholic Fatty Liver Disease: Evidence from Human Studies. Cells 10(7), 1822;, Paper

Mohammad S, Al Zoubi S, Collotta D, Krieg N, Wissuwa B, Ferreira Alves G, Purvis GSD, Norata GD, Baragetti A, Catapano AL, Solito E, Zechendorf E, Schürholz T, Correa W, Brandenburg K, Coldewey SM, Collino M, Yaqoob MM, Martin L, Thiemermann C (2021) A synthetic peptide designed to neutralize lipopolysaccharides attenuates metaflammation and diet-induced metabolic derangement in mice. Front Immunol.,, Paper

Press AT, Babic P, Hoffmann B, Müller T, Foo W, Hauswald W, Benecke J, Beretta M, Cseresnyés Z, Hoeppener S,
Nischang I, Coldewey SM, Gräler MH, Bauer R, Gonnert F, Gaßler N, Wetzker R, Figge MT, Schubert US, Bauer M (2021) Targeted delivery of a phosphoinositide 3-kinase inhibitor to restore organ function in sepsis. EMBO Mol Med.: e14436, Paper

Chung HY, Neu C, Wickel J, Kuckertz SL, Coldewey SM (2021) Neurofilament light chain in patients with COVID-19 and bacterial pneumonia. Ann Neurol. 90(1):174-175. doi: 10.1002/ana.26135, Letter

König R, Kolte A, Ahlers O, Oswald M, Krauss V, Roell D, Sommerfeld O, Dimopoulos G, Tsangaris I, Antoniadou E, Jaishankar N, Bogatsch H, Löffler M, Rödel M, Garcia-Moreno M, Tuchscherr L, Sprung CL, Singer M, Brunkhorst F, Oppert M, Gerlach H, Claus RA, Coldewey SM, Briegel J, Giamarellos-Bourboulis EJ, Keh D, Bauer M (2021) Use of IFNγ/IL10 Ratio for Stratification of Hydrocortisone Therapy in Patients With Septic Shock. Front Immunol. 12:607217, doi: 10.3389/fimmu.2021.607217, Paper


Baumbach P, Schmidt-Winter C, Hoefer J, Derlien S, Best N, Herbsleb M, Coldewey SM (2020) A Pilot Study on the Association of Mitochondrial Oxygen Metabolism and Gas Exchange during Cardiopulmonary Exercise Testing: Is there a Mitochondrial Threshold? Front. Med. 7:585462. doi: 10.3389/fmed.2020.585462, Paper

O'Riordan CE, Purvis GSD, Collotta D, Wissuwa B, Sheikh MH, Ferreira Alves G, Krieg N, Mohammad S, Callender LA, Coldewey SM, Collino M, Greaves DR, Thiemermann C (2020) X-linked immunodeficient mice with no functional Bruton's Tyrosine Kinase are protected from sepsis-induced multiple organ failure. Front. Immunol. 11:581758, Paper

Nicklas JY, Diener O, Leistenschneider M, Sellhorn C, Schön G, Winkler M, Daum G, Schwedhelm E, Schröder J, Fisch M, Schmalfeldt B, Izbicki JR, Bauer M, Coldewey SM, Reuter DA, Saugel B (2020) Personalised haemodynamic management targeting baseline cardiac index in high-risk patients undergoing major abdominal surgery: a randomised single-centre clinical Trial. Br. J. Anaesth. 125(2):122-132, Paper

Stallmach A, Kortgen A, Gonnert F, Coldewey SM, Reuken P, Bauer M (2020) Infliximab against severe COVID-19-induced cytokine storm syndrome with organ failure-a cautionary case series. Crit Care. 24(1):444, Paper

Gläser A, Hammerl F, Gräler MH, Coldewey SM, Völkner C, Frech MJ, Yang F, Luo J, Tönnies E, von Bohlen und Halbach O, Brandt N, Heimes D, Neßlauer A-M, Korenke GC, Owczarek-Lipska M, Neidhardt J, Rolfs A, Wree A, Witt M, Bräuer AU (2020) Identification of Brain-Specific Treatment Effects in NPC1 Disease by Focusing on Cellular and Molecular Changes of Sphingosine-1-Phosphate Metabolism. Int. J. Mol. Sci. 21, 4502; Paper

Coldewey SMNeu C, Baumbach P, Scherag A, Goebel B, Ludewig K, Bloos F, Bauer M (2020) Identification of cardiovascular and molecular prognostic factors for the medium-term and long-term outcomes of sepsis (ICROS): protocol for a prospective monocentric cohort study. BMJ Open 10:e036527, Paper

Neu CLange AIWissuwa BColdewey SM (2020) Mikrozirkulationsstörung in der Sepsis. DIVI 2020; 11: 66–73, DOI 10.3238/DIVI.2020.0066-0073

Sobbe IV, Krieg N, Dennhardt S, Coldewey SM (2020) Involvement of NF-κB1 and the Non-Canonical NF-κB Signaling Pathway in the Pathogenesis of Acute Kidney Injury in Shiga-Toxin-2-Induced Hemolytic-Uremic Syndrome in Mice. Shock. 56(4):573-58. doi: 10.1097/SHK.0000000000001558 Paper

Neu C, Baumbach P, Plooij AK, Skitek K, Götze J, von Loeffelholz C, Schmidt-Winter C, Coldewey SM (2020) Non-Invasive Assessment of Mitochondrial Oxygen Metabolism in the Critically Ill Patient Using the Protoporphyrin IX‐Triplet State Lifetime Technique – a Feasibility Study. Front. Immunol. 11:757, Paper

Zechendorf E, O'Riordan CE, Stiehler L, Wischmeyer N, Chiazza F, Collotta D, Denecke B, Ernst S, Müller-Newen G, Coldewey SM, Wissuwa B, Collino M, Simon TP, Schuerholz T, Stoppe C, Marx G, Thiemermann C, Martin L (2020) Ribonuclease 1 attenuates septic cardiomyopathy and cardiac apoptosis in a murine model of polymicrobial sepsis. JCI Insight 5(8):e131571, Paper

Stepanovska B, Lange AI, Schwalm S, Pfeilschifter J, Coldewey SM, Huwiler A (2020) Downregulation of S1P lyase improves barrier function in human cerebral microvascular endothelial cells following an inflammatory challenge. Int. J. Mol. Sci. 21(4), 1240; Paper

Sponholz C, Schuwirth C, Koenig L, Hoyer H, Coldewey SM, Schelenz C, Doenst T, Kortgen A, Bauer M (2020) Intraoperative reduction of vasopressors using processed electroencephalographic monitoring in patients undergoing elective cardiac surgery: a randomized clinical trial. J Clin Monit Comput. 34(1):71-80. Paper 


Coldewey, SM, Neu, C (2019) Dysfunktion von Herz, Kreislauf und Mitochondrien im septischen Schock: Physiologischer Winterschlaf oder metabolischer Albtraum? IntensivNews, Jahrgang 23, Ausgabe 4/2019

O'Riordan CE, Purvis GSD, Collotta D, Chiazza F, Wissuwa B, Zoubi S, Stiehler L, Martin L, Coldewey SM, Collino M, Thiemermann C (2019) Bruton's Tyrosine Kinase Inhibition Attenuates the Cardiac Dysfunction Caused by Cecal Ligation and Puncture in Mice. Front. Immunol. 10:2129, Paper

Dennhardt S, Finke KR, Huwiler A, Coldewey SM (2019) Sphingosine-1-phosphate promotes barrier-stabilizing effects in human microvascular endothelial cells via AMPK-dependent mechanisms. Biochimica et Biophysica Acta (BBA) - Molecular Basis of Disease 1865(4):774-781, Paper

Baumbach P, Neu C, Derlien S, Bauer M, Nisser M, Buder A, Coldewey SM (2019) A pilot study of exercise-induced changes in mitochondrial oxygen metabolism measured by a cellular oxygen metabolism monitor (PICOMET). Biochim Biophys Acta Mol Basis Dis. 1865(4):749-758, Paper


Bauer M, Coldewey SM, Leitner M, Löffler B, Weis S, Wetzker R (2018) Deterioration of Organ Function as a Hallmark in Sepsis: The Cellular Perspective. Front Immunol. 9:1460, Paper

Dennhardt S, Pirschel W, Wissuwa B, Daniel C, Gunzer F, Lindig S, Medyukhina A, Kiehntopf M, Rudolph WW, Zipfel PF, Gunzer M, Figge MT, Amann K, Coldewey SM (2018) Modeling Hemolytic-Uremic Syndrome: In-Depth Characterization of Distinct Murine Models Reflecting Different Features of Human Disease. Front Immunol. 9, Article 1459, Paper

Wissuwa B, Heinemann SH, Bauer M, Coldewey SM (2018) Studies into Slo1 K+ channels and their ligand docosahexaenoic acid in murine sepsis to delineate off-target effects of immunonutrition. Life Sci. 203:112-120, Paper

Meinel C, Spartà G, Dahse HM, Hörhold F, König R, Westermann M, Coldewey SM, Cseresnyés Z, Figge MT, Hammerschmidt S, Skerka C, Zipfel PF (2018) Streptococcus pneumoniae From Patients With Hemolytic Uremic Syndrome Binds Human Plasminogen via the Surface Protein PspC and Uses Plasmin to Damage Human Endothelial Cells. J Infect Dis. 217(3):358-370, Paper


Weis S, Dickmann P, Pletz MW, Coldewey SM, Gerlach H, Bauer M (2017) Eine neue Definition führt zu neuen Konzepten. Dtsch Arztebl. 29-30: A1424-A1428, A6-A7.

Wöchtl B, Gunzer F, Gerner W, Gasse H, Koch M, Bagó Z, Ganter M, Weissenböck H, Dinhopl N, Coldewey SM, von Altrock A, Waldmann KH, Saalmüller A, Zimmermann K, Steinmann J, Kehrmann J, Klein-Hitpass L, Blom J, Ehricht R, Engelmann I, Hennig-Pauka I (2017) Comparison of clinical and immunological findings in gnotobiotic piglets infected with Escherichia coli O104:H4 outbreak strain and EHEC O157:H7. Gut Pathog. 9:30, Paper

Dickmann P, Scherag A, Coldewey SM, Sponholz C, Brunkhorst FM, Bauer M (2017) [Epistemology in the intensive care unit-what is the purpose of a definition? : Paradigm shift in sepsis research]. Der Anaesthesist 66:622–625 Paper

Seidel RA, Claudel T, Schleser FA, Ojha NK, Westerhausen M, Nietzsche S, Sponholz C, Cuperus F, Coldewey SM, Heinemann SH, Pohnert G, Trauner M, Bauer M (2017) Impact of higher-order heme degradation products on hepatic function and hemodynamics. J Hepatol., pii: S0168-8278(17)30208-8. Paper


Coldewey SM, Benetti E, Collino M, Pfeilschifter J, Sponholz C, Bauer M, Huwiler A, Thiemermann C (2016) Elevation of serum sphingosine-1-phosphate attenuates impaired cardiac function in experimental sepsis. Sci. Rep. 6:27594, doi: 10.1038/srep27594.

Gobbetti T, Coldewey SM, Chen J, McArthur S, le Faouder P, Cenac N, Flower RJ, Thiemermann C, Perretti M (2014) Nonredundant protective properties of FPR2/ALX in polymicrobial murine sepsis. Proc. Natl. Acad. Sci. U S A 111(52):18685-90, doi: 10.1073/pnas.1410938111.

Coldewey SM, Thiemermann C (2014) Pleiotropic effects of atorvastatin in experimental sepsis: preservation of β1-adrenoreceptor signaling in the heart. Shock. 41(5):458-9, doi: 10.1097/SHK.0000000000000154. No abstract available.

Chen J, Chiazza F, Collino M, Patel NS, Coldewey SM, Thiemermann C (2014) Gender dimorphism of the cardiac dysfunction in murine sepsis: signalling mechanisms and age-dependency. PLoS One. 9(6):e100631, doi: 10.1371/journal.pone.0100631.

Coldewey SM, Rogazzo M, Collino M, Patel NS, Thiemermann C (2013) Inhibition of IκB kinase reduces the multiple organ dysfunction caused by sepsis in the mouse. Dis. Model. Mech. 6(4):1031-42, doi: 10.1242/dmm.012435.

Coldewey SM, Khan AI, Kapoor A, Collino M, Rogazzo M, Brines M, Cerami A, Hall P, Sheaff M, Kieswich JE, Yaqoob MM, Patel NS, Thiemermann C (2013) Erythropoietin attenuates acute kidney dysfunction in murine experimental sepsis by activation of the β-common receptor. Kidney Int. 84(3):482-90, doi: 10.1038/ki.2013.118.

Khan AI, Coldewey SM, Patel NS, Rogazzo M, Collino M, Yaqoob MM, Radermacher P, Kapoor A, Thiemermann C (2013) Erythropoietin attenuates cardiac dysfunction in experimental sepsis in mice via activation of the β-common receptor. Dis. Model. Mech. 6(4):1021-30, doi: 10.1242/dmm.011908.

Jüttner B, Kröplin J, Coldewey SM, Witt L, Osthaus WA, Weilbach C, Scheinichen D (2008) Unsaturated long-chain fatty acids induce the respiratory burst of human neutrophils and monocytes in whole blood. Nutr. Metab. (Lond). 5:19, doi: 10.1186/1743-7075-5-19.

Kieckbusch H, Coldewey SM, Hollenhorst J, Haeseler G, Hillemanns P, Hertel H (2008) Patent blue sentinel node mapping in cervical cancer patients may lead to decreased pulse oximeter readings and positive methaemoglobin results. Eur. J. Anaesthesiol. 25(5):365-8, doi: 10.1017/S0265021508003578.

Coldewey SM, Hartmann M, Schmidt DS, Engelking U, Ukena SN, Gunzer F (2007) Impact of the rpoS genotype for acid resistance patterns of pathogenic and probiotic Escherichia coli. BMC Microbiol. 7:21.

Ukena SN, Westendorf AM, Hansen W, Rohde M, Geffers R, Coldewey S, Suerbaum S, Buer J, Gunzer F (2005) The host response to the probiotic Escherichia coli strain Nissle 1917: specific up-regulation of the proinflammatory chemokine MCP-1. BMC Med Genet. 6:43.