Clinical Septomics
As part of the 1st funding phase of the ZIK Septomics, the Paul Martini Research Group Clinical Septomics, headed by Prof. Dr. med. Frank M. Brunkhorst, incorporated its clinical expertise into research on the development of sepsis. The group thus was an important link between basic research and clinical practice. Clinical Septomics was responsible for the collection and preparation of patient samples for cellular or microbiological examinations and placed them in the bio-sample bank. From there, they could be used to further address scientific questions of the ZIK Septomics research groups. In addition, the group was responsible for reviewing research results for their potential clinical benefit as well as the training of clinical trial staff. Prof. Frank M. Brunkhorst was awarded the endowed professorship for “Clinical Sepsis Research” of the Paul Martini Foundation in 2008. The research group was mainly financed by the Free State of Thuringia by the STIFT foundation (Stiftung Technologie, Innovation und Forschung Thüringen).
Leitung
Prof. Dr. med. Martin Brunkhorst
Publications
Weimann A, Kern BR, Löffler M, Sablotzki A, Thiele F, Brunkhorst FM (2013) Enrolment of intensive care patients in clinical studies. Ethical, legal and organizational problems from an interdisciplinary point of view. Med Klin Intensivmed Notfmed. 108(4):303-10.
Wacker C, Prkno A, Brunkhorst FM, Schlattmann P (2013) Procalcitonin as a diagnostic marker for sepsis: a systematic review and meta-analysis. Lancet Infect Dis. 13(5):426-35.
Brunkhorst FM (2013) Hospital-acquired infections--tribute to high-performance medicine. Dtsch Med Wochenschr. 138(34-35):1705.
Hagel S, Pletz MW, Brunkhorst FM, Seifert H, Kern WV (2013) Bacteremia and Sepsis. Internist (Berl). 54(4):399-407.
Zielske J, Bohne S, Axer H, Brunkhorst FM, Guntinas-Lichius O (2013) Dysphagia management of acute and long-term critically ill intensive care patients. Med Klin Intensivmed Notfmed. 109(7):516-25.
Peltola L, Goddia C, Namboya F, Brunkhorst FM, Pollach G (2013) Sepsis - Knowledge of non-physician personnel in Africa. A cross-sectional study in Malawian district hospitals. Med Klin Intensivmed Notfmed. 110(1):49-54.
Prkno A, Wacker C, Brunkhorst FM, Schlattmann P (2013) Procalcitonin-guided therapy in intensive care unit patients with severe sepsis and septic shock--a systematic review and meta-analysis. Crit Care. 17(6):R291.
Weimann A, Kern BR, Löffler M, Sablotzki A, Thiele F, Brunkhorst FM (2013) Enrolment of intensive care patients in clinical studies. Ethical, legal and organizational problems from an interdisciplinary point of view. Med Klin Intensivmed Notfmed. 108(4):303-10.
Schädler D, Elke G, Engel C, Bogatsch H, Frerichs I, Kuhlen R, Rossaint R, Quintel M, Scholz J, Brunkhorst FM, Loeffler M, Reinhart K, Weiler N; German Competence Network Sepsis (SepNet) (2013) Ventilatory strategies in septic patients. Results from a nationwide observational trial. Anaesthesist. 2013 Jan;62(1):27-33.
Grimm A, Teschner U, Porzelius C, Ludewig K, Zielske J, Witte OW, Brunkhorst FM, Axer H (2013) Muscle ultrasound for early assessment of critical illness neuromyopathy in severe sepsis. Crit Care. 17(5):R227.
Frosinski JJ & Brunkhorst FM (2013) Peripheral venous catheter-related E. faecalis sepsis with fatal outcome. Dtsch Med Wochenschr. 138(34-35):1723-6.
Elke G, Kuhnt E, Ragaller M, Schädler D, Frerichs I, Brunkhorst FM, Löffler M, Reinhart K, Weiler N; German Competence Network Sepsis (SepNet) (2013) Enteral nutrition is associated with improved outcome in patients with severe sepsis. A secondary analysis of the VISEP trial. Med Klin Intensivmed Notfmed. 108(3):223-33.
Kaasch AJ, Rieg S, Kuetscher J, Brodt HR, Widmann T, Herrmann M, Meyer C, Welte T, Kern P, Haars U, Reuter S, Hübner I, Strauss R, Sinha B, Brunkhorst FM, Hellmich M, Fätkenheuer G, Kern WV, Seifert H; preSABATO study group (2013) Delay in the administration of appropriate antimicrobial therapy in Staphylococcus aureus bloodstream infection: a prospective multicenter hospital-based cohort study. Infection. 41(5):979-85.
Schmitz RP, Keller PM, Baier M, Hagel S, Pletz MW, Brunkhorst FM (2013) Quality of blood culture testing - a survey in intensive care units and microbiological laboratories across four European countries Crit Care. 17(5):R248.
Axer H, Grimm A, Porzelius C, Teschner U, Schumacher U, Witte OW, Brunkhorst FM (2013) Impairment of small somatic and autonomic nerve fibres in intensive care unit patients with severe sepsis and critical illness polyneuropathy--a single center controlled observational study. BMC Neurol. 13:159.
Wittbrodt P, Haase N, Butowska D, Winding R, Poulsen JB, Perner A; 6S trial group; Scandinavian Critical Care Trials Group (2013) Quality of life and pruritus in patients with severe sepsis resuscitated with hydroxyethyl starch long-term follow-up of a randomised trial. Crit Care. 17(2):R58.
Rosendahl J, Brunkhorst FM, Jaenichen D, Strauss B (2013) Physical and mental health in patients and spouses after intensive care of severe sepsis: a dyadic perspective on long-term sequelae testing the Actor-Partner Interdependence Model. Crit Care Med. 41(1):69-75.
Brunkhorst FM (2013) Volume therapy: hydroxyethyl starch or saline? Hydroxyethyl starch in intensive care patients: there's an end of it! Dtsch Med Wochenschr. 138(3):66.
Hagel S, Ludewig K, Frosinski J, Hutagalung R, Porzelius C, Gastmeier P, Harbarth S, Pletz MW, Brunkhorst FM (2013) Effectiveness of a hospital-wide educational programme for infection control to reduce the rate of health-care associated infections and related sepsis (ALERTS)--methods and interim results. Dtsch Med Wochenschr. 138(34-35):1717-22.
Brunkhorst FM (2012) Does hypoglycaemia increase mortality risk in critical ill patients? Intensive insulin treatment is only recommended in clinical trials. Dtsch Med Wochenschr. 137(46):2360.
Bohne S, Schelhorn-Neise P, Brunkhorst FM, Guntinas-Lichius O (2012) Severe organic dysphagia after long-term ventilation in a patient with sepsis and multiorgan failure. Med Klin Intensivmed Notfmed. 107(7):564-6.
Brunkhorst FM, Oppert M, Marx G, Bloos F, Ludewig K, Putensen C, Nierhaus A, Jaschinski U, Meier-Hellmann A, Weyland A, Gründling M, Moerer O, Riessen R, Seibel A, Ragaller M, Büchler MW, John S, Bach F, Spies C, Reill L, Fritz H, Kiehntopf M, Kuhnt E, Bogatsch H, Engel C, Loeffler M, Kollef MH, Reinhart K, Welte T; German Study Group Competence Network Sepsis (SepNet) (2012) Effect of empirical treatment with moxifloxacin and meropenem vs meropenem on sepsis-related organ dysfunction in patients with severe sepsis: a randomized trial. JAMA.307(22):2390-9.
Jaenichen D, Brunkhorst FM, Strauss B, Rosendahl J (2012) Physical and mental long-term sequelae following intensive care of severe sepsis in patients and relatives. Psychother Psychosom Med Psychol. 62(9-10):335-43.
Schmerler D, Neugebauer S, Ludewig K, Bremer-Streck S, Brunkhorst FM, Kiehntopf M (2012) Targeted metabolomics for discrimination of systemic inflammatory disorders in critically ill patients. J Lipid Res. 53(7):1369-75.
Reuken PA, Bruns T, Zimmer B, Michael A, Brunkhorst FM, Pletz MW, Stallmach A (2012) Recurrent fever and bacteraemia after endoscopic variceal haemostasis with cyanoacrylate: a case report. Infection. 40(3):351-3.
Kiehntopf M, Schmerler D, Brunkhorst FM, Winkler R, Ludewig K, Osterloh D, Bloos F, Reinhart K, Deufel T (2011) Mass spectometry-based protein patterns in the diagnosis of sepsis/systemic inflammatory response syndrome. Shock. 36(6):560-9.
Bloos F, Marshall JC, Dellinger RP, Vincent JL, Gutierrez G, Rivers E, Balk RA, Laterre PF, Angus DC, Reinhart K, Brunkhorst FM (2011) Multinational, observational study of procalcitonin in ICU patients with pneumonia requiring mechanical ventilation: a multicenter observational study. Crit Care. 15(2):R88.
Hartog CS, Brunkhorst FM, Engel C, Meier-Hellmann A, Ragaller M, Welte T, Kuhnt E, Reinhart K; Deutsche Studiengruppe Kompetenznetzwerk Sepsis (SepNet) (2011) Are renal adverse effects of hydroxyethyl starches merely a consequence of their incorrect use? Wien Klin Wochenschr. 123(5-6):145-55.
Knapp J, Marx G, Weismüller K, Steinebach S, Lichtenstern C, Popp E, Mayer K, Brunkhorst FM, Weigand MA, Bernhard M. (2011) Update: studies in intensive care medicine. Results of the last 12 months. Anaesthesist. 60(11):1041-56.
Graf J, Reinhold A, Brunkhorst FM, Ragaller M, Reinhart K, Loeffler M, Engel C; German Competence Network Sepsis (SepNet) (2010) Variability of structures in German intensive care units--a representative, nationwide analysis. Wien Klin Wochenschr. 122(19-20):572-8.
Brunkhorst FM, Gastmeier P, Kern W, Krüger W, Mayer K, Weimann A, Welte T, Putensen C, Werdan K, Reinhart K (2010) Prevention and follow-up care of sepsis. 1st revision of S2k guidelines of the German Sepsis Society (Deutsche Sepsis-Gesellschaft e.V., DSG) and the German Interdisciplinary Association of Intensive Care and Emergency Medicine (Deutsche Interdisziplinäre Vereinigung für Intensiv- und Notfallmedizin, DIVI). Internist (Berl). 51(7):925-32.
Reinhart K, Brunkhorst FM, Bone HG, Bardutzky J, Dempfle CE, Forst H, Gastmeier P, Gerlach H, Gründling M, John S, Kern W, Kreymann G, Krüger W, Kujath P, Marggraf G, Martin J, Mayer K, Meier-Hellmann A, Oppert M, Putensen C, Quintel M, Ragaller M, Rossaint R, Seifert H, Spies C, Stüber F, Weiler N, Weimann A, Werdan K, Welte T; German Sepsis Society; German Interdisciplinary Association of Intensive Care and Emergency Medicine (2010) Prevention, diagnosis, therapy and follow-up care of sepsis: 1st revision of S-2k guidelines of the German Sepsis Society (Deutsche Sepsis-Gesellschaft e.V. (DSG)) and the German Interdisciplinary Association of Intensive Care and Emergency Medicine (Deutsche Interdisziplinäre Vereinigung für Intensiv- und Notfallmedizin (DIVI)). Ger Med Sci. 8:Doc14.
Beale R, Janes JM, Brunkhorst FM, Dobb G, Levy MM, Martin GS, Ramsay G, Silva E, Sprung CL, Vallet B, Vincent JL, Costigan TM, Leishman AG, Williams MD, Reinhart K (2010) Global utilization of low-dose corticosteroids in severe sepsis and septic shock: a report from the PROGRESS registry. Crit Care. 14(3):R102.
Reinhart K, Brunkhorst FM, Bone HG, Bardutzky J, Dempfle CE, Forst H, Gastmeier P, Gerlach H, Gründling M, John S, Kern W, Kreymann G, Krüger W, Kujath P, Marggraf G, Martin J, Mayer K, Meier-Hellmann A, Oppert M, Putensen C, Quintel M, Ragaller M, Rossaint R, Seifert H, Spies C, Stüber F, Weiler N, Weimann A, Werdan K, Welte T; German Interdisciplinary Association for Intensive and Emergency Care Medicine; German Sepsis Society (2010) Prevention, diagnosis, treatment, and follow-up care of sepsis. First revision of the S2k Guidelines of the German Sepsis Society (DSG) and the German Interdisciplinary Association for Intensive and Emergency Care Medicine (DIVI). Anaesthesist. 59(4):347-70.
Bernhard M, Marx G, Weismüller K, Lichtenstern C, Mayer K, Brunkhorst FM, Weigand MA (2010) Results of studies in critical care medicine in the year 2009: update. Anaesthesist. 59(5):453-76.
Brunkhorst FM (2010) Tight glucose control in intensive care patients--contra. Dtsch Med Wochenschr. 135(14):705.
Pletz MW, Bloos F, Burkhardt O, Brunkhorst FM, Bode-Böger SM, Martens-Lobenhoffer J, Greer MW, Stass H, Welte T (2010) Pharmacokinetics of moxifloxacin in patients with severe sepsis or septic shock. Intensive Care Med. 36(6):979-83.
Reinhart K, Hartog CS, Brunkhorst FM (2010) Hydroxyethyl starches: Plus ça change, plus c'est la même chose. Anesthesiology. 112(3):756-7.
Hartog CS, Brunkhorst FM, Bloos F, Bogatsch H, Engel C, Sengebusch K, Reinhart K, Ragaller M (2010) Practice of volume therapy in patients with severe sepsis: results from a nationwide sepsis prevalence study. Intensive Care Med. 36(3):553-4.
Briegel J, Sprung CL, Annane D, Singer M, Keh D, Moreno R, Möhnle P, Weiss Y, Avidan A, Brunkhorst FM, Fiedler F, Vogeser M; CORTICUS Study Group (2009) Multicenter comparison of cortisol as measured by different methods in samples of patients with septic shock. Intensive Care Med. 35(12):2151-6.
Martin G, Brunkhorst FM, Janes JM, Reinhart K, Sundin DP, Garnett K, Beale R (2009) The international PROGRESS registry of patients with severe sepsis: drotrecogin alfa (activated) use and patient outcomes. Crit Care. 13(3):R103.
Brunkhorst FM, Reinhart K (2009) Diagnosis and causal treatment of sepsis. Internist (Berl). 50(7):810-6.
Brunkhorst FM, Reinhart K (2009) Supportive and adjunctive sepsis therapy. Internist (Berl). 50(7):817-24, 826-7.
Beale R, Reinhart K, Brunkhorst FM, Dobb G, Levy M, Martin G, Martin C, Ramsey G, Silva E, Vallet B, Vincent JL, Janes JM, Sarwat S, Williams MD; PROGRESS Advisory Board (2009) Promoting Global Research Excellence in Severe Sepsis (PROGRESS): lessons from an international sepsis registry. Infection. 37(3):222-32.
Claus RA, Bockmeyer CL, Budde U, Kentouche K, Sossdorf M, Hilberg T, Schneppenheim R, Reinhart K, Bauer M, Brunkhorst FM, Lösche W (2009) Variations in the ratio between von Willebrand factor and its cleaving protease during systemic inflammation and association with severity and prognosis of organ failure. Thromb Haemost. 101(2):239-47.