Development of Resistance in Pathogenic Fungi

In the last 20 years, the clinical relevance of antimycotic resistance has increased considerably. In addition to the global spread of Candida auris, azole-resistant Aspergillus fumigatus isolates have been increasingly identified since the mid-1990s, regularly leading to failure of primary therapy. With the increased use of echinocandins, resistant Candida isolates (especially C. glabrata) have appeared since the 2000s.