The therapeutic use of Bruton tyrosine kinase inhibitors in Shiga toxin-mediated HUS.
New insights published on the therapeutic potential of Bruton tyrosine kinase inhibitors (BTKi) in Shiga toxin-induced hemolytic uremic syndrome.
Hemolytic uremic syndrome (HUS) is a serious disorder that can develop following oral infection with Shiga toxin (Stx)-producing Escherichia coli (STEC). In this case, HUS is clinically manifested by …
Gene switch of the Candida albicans toxin Candidalysin under the magnifying glass
Functional analysis of the ECE1 Promoter published in Microbiology Spectrum
Hyphae formation of Candia albicans, a key virulence trait of the human pathogenic fungus, is associated with the secretion of the cytotoxin Candidalysin. The toxic peptide contributes greatly to the …
Candida albicans biofilm formation requires stable amino acid homeostasis
Multi-OMICs study about Candida albicans amino acid metabolism during biofilm formation published in npj Biofilms and Microbiomes
Candida albicans is part of the human microbiota, colonizing mucosal surfaces. Under certain circumstances, e. g. impaired immune functions, the fungus can become invasive and cause infections. In thi…
The role of erythropoietin in Shiga toxin-mediated HUS
New insights published on the therapeutic potential of erythropoietin and non-hematopoietic peptide analogues in Shiga toxin-induced hemolytic-uremic syndrome
Infections with Shiga toxin-producing Escherichia coli (STEC) can cause a serious complication called hemolytic-uremic syndrome (HUS). In addition to acute kidney injury, this condition is characteriz…
Poster prize for Anna Möslinger
Anna Möslinger, PhD student of the JRG Host Fungal Interfaces (Head: Slavena Vylkova, PhD), received the Hans Rieth poster prize 2022 for her work “Candida albicans protein kinase Rim11 is involved in…
Related, but on different missions
Functions of two new kinases in Candida albicans elucidated
The human pathogenic fungus Candida albicans is part of the healthy human microbiota. However, under certain circumstances the fungus can invade host tissue and become pathogenic causing superficial o…
Antibiotic resistant pathogens – an increasing problem in hospitals: Can a probiotic cleaning regime help?
Comparative study on surface sanitation protocols in a hospital published
Antibiotic resistant pathogens play an increasing role in hospital acquired infections. The extent to which the spread of these pathogens is promoted by surfaces is not yet clear. In a study conducted…
Significance of haptoglobin and hemopexin in Shiga toxin-mediated HUS
New paper published on the role of haptoglobin and hemopexin in the development of Shiga toxin-induced hemolytic uremic syndrome (HUS)
Hemolytic uremic syndrome (HUS) is a renal disease that can be caused by infection with Shiga toxin-producing Escherichia coli (STEC) and is characterized by acute renal failure, thrombocytopenia, and…
Highly specific proline transporter identified in Candida albicans
New paper published on the role of amino acid uptake for metabolic and stress adaptation in Candida albicans
The yeast Candida albicans is capable of utilizing a variety of nutrients, which allows the fungus to colonize and infect different host niches. Amino acids are abundant carbon and nitrogen sources in…
"Entstehung einer künstlerischen Tatsache"
Science meets arts at TRAFO Jena
As part of the Jena art project "Entstehung einer künstlerischen Tatsache" (Emergence of an Artistic Fact), scientists from the junior research group Host Fungal Interfaces and the research group head…