Poster award to Philipp Brandt - Congratulations!
Philipp Brandt, PhD student at JRG Host Fungal Interfaces (headed by Dr. Slavena Vylkova), was awarded a poster prize at "Myk 2020" for his analyses of previously unknown functions of protein kinases …
A slimy matter
Case report of catheter-associated bloodstream infection with a non-frequent opportunistic pathogen published
Bloodstream infections originating from a catheter contaminated with pathogens are not uncommon in intensive care units. Pathogens accumulate on the catheter surface and can form aggregates - so-calle…
Catch the wave!
Metabolome analyses in human pathogenic fungi described in a Pearl
As metabolome analyses allow the identification and quantification of the complete set of metabolites of a biological specimen to a given time point, this rather novel OMICS-tool is beginning to be us…
Clinical Candida albicans vaginal isolates differ
First comparative study on Candida albicans vaginal isolates in their interaction with macrophages published
Vulvovaginal candidiasis is one of the most common fungal infections in humans and is mainly caused by the species Candida albicans. In order to analyze the infection process better, clinical isolates…
Wolfgang Vivas successfully defended his PhD thesis “Modulation of Dendritic Cell Function by the fungal Quorum Sensing Molecule Farnesol” on June 23rd, 2020. He conducted his PhD project in the Funga…
Activation of the immunoregulatory transcription factors NF-κB1 and -2 in HUS
Participation of canonical and non-canonical NF-κB signaling pathway in renal damage in hemolytic-uremic syndrome
The hemolytic-uremic syndrome (HUS) is a thrombotic microangiopathy that can occur as a severe systemic complication following infection with shiga toxin-producing Escherichia coli (STEC). T…
Cellular oxygen metabolism relevant for the diagnosis of sepsis?
New technique enables measurement of cellular oxygen metabolism in critically ill patients
Disturbed tissue oxygenation as a result of a mismatch between oxygen supply and oxygen consumption is one of the main features of septic shock. The mitochondria are primarily responsible for the regu…
Prof. Dr. Hortense Slevogt at "DGP aktuell"
Prof. Dr. Hortense Slevogt, head of the Host Septomics research group for infection and microbiomics research, at DGP aktuell about strategies for COVID-19 treatment. …
Candida albicans biofilms require the transcription factor Stp2
New role of the transcription factor Stp2 published in Frontiers in Microbiology
The pathogenic fungus Candida albicans forms biofilms in the human host, especially on abiotic surfaces such as central venous catheters, which can cause severe infections and sepsis. These infections…
Regulation of hyphal formation of the human pathogenic fungus Candida albicans further elucidated
Joint publication of Fungal Septomics and Host Fungal Interfaces in mBio
The human pathogenic fungus Candida albicans is the leading cause of invasive Candida infections, which often lead to sepsis. The fungus can grow in different morphologies and changes between yeast st…