Long-term model of HUS: from acute to chronic kidney disease
10.10.2024
Hemolytic uremic syndrome (HUS), which can occur as a systemic complication of an infection with Shiga toxin-producing enterohemorrhagic Escherichia coli (EHEC), is clinically manifested by a symptom triage consisting of a lack of blood platelets (thrombocytopenia), microangiopathic hemolytic anemia (loss of red blood cells due to damage of small blood vessels) and acute kidney failure. Almost half of the patients later suffer from the long-term consequences of HUS, primarily chronic kidney disease (CKD). Little is known about the mechanisms that play a role in the progression from acute kidney failure to chronic kidney disease.
UKJ staff from the Translational Septomics research group and the Department of Internal Medicine III (Nephrology) have succeeded in establishing and characterizing a Shiga toxin-induced long-term model of HUS, which can be used to analyse the mechanisms underlying the transition from acute kidney failure to CKD, among other things. In addition, the model can be used to test therapeutic approaches that counteract the development of CKD in HUS patients.
Wegener J, Dennhardt S, Löffler I, Coldewey SM (2024) Transition from acute kidney injury to chronic kidney disease in a long-term murine model of Shiga toxin-induced hemolytic-uremic syndrome. Front. Immunol., 10 October 2024 Sec. Inflammation Volume 15 - 2024. doi.org/10.3389/fimmu.2024.1469353