Prof. Sina Coldewey is a project management member of two new projects of the SFB PolyTarget
23.07.2021
The aim of the collaborative research centre (SFB) PolyTarget is to develop new strategies for the treatment of infection-related inflammatory conditions. To this end, polymer-based nanoparticles are to be developed which, as carriers of specific active substances, bring them selectively and specifically to their site of action. Undesirable side effects, e.g. caused by the systemic spread of the active substances in the organism, could thus be prevented or reduced.
In the transfer project T01 "Targeting renal phosphoinositide 3-kinase γ (PI3Kγ) using dye-labelled nanoparticles", led by Prof. Michael Bauer, Prof. Sina Coldewey and Prof. Ulrich Schubert, functionalised nanoparticles are to be designed. These drug-loaded particles can bind organic anion transporters by means of specific dye coupling and thus ensure compartment-specific application of the drug in the kidneys. The dye labelling of the nanoparticles additionally allows the comprehensive analysis of the induced in vitro and in vivo effects.
In the project A02 "Multifunctional polysaccharide-based nanoparticles for targeted drug delivery with two-stage release characteristics" led by Prof. Sina Coldewey, Prof. Thomas Heinze and Prof. Thorsten Heinzel, functional nanoparticles acting as drug carriers are to be modified to achieve tissue specificity for anti-inflammatory and tissue-protective compounds. Histone deacetylase inhibitors (HDACi), which have an influence on the regulation of the immune system by deacetylating proteins, among other things, are considered as possible active substances. Improved tissue specificity as a result of the target-specific binding nanoparticles can significantly expand the spectrum of new active substances for the therapy of inflammatory diseases.