The development of new treatment concepts for sepsis requires an improvement of our molecular understanding of the disease. This includes the virulence mechanisms of the triggering microorganisms as well as the molecular processes of the host response which are crucial for the development and progression of the syndrome. In the context of the altered perception of sepsis, which is now primarily understood as an organ dysfunction in the context of an inadequate host response (and not only of the immune system), a focus of the junior research group is investigating the importance of the molecular mechanisms behind these organ failures.
The Translational Septomics group employs different in vitro and in vivo model systems to investigate the molecular mechanisms of sepsis.
The aim is
- to evaluate and verify candidate molecules from the clinical study as biomarkers and theragnostics
- to preclinically verify established and new target molecules for cardiovascular function
- to identify and evaluate pharmacological intervention strategies
The investigations focus on the relevance of cardiovascular changes for acute sepsis and for the long-term results of survivors.
The group also focuses on the importance and treatment of acute renal failure, which can occur in the context of infectious diseases such as sepsis and HUS.