Principle investigator

Prof. Sina M. Coldewey, MD, PhD

Prof. Sina M. Coldewey, MD, PhD


Phone: +49 3641 9-396530


Curriculum vitae

Medical career

Since 09/2020 Head of the Division of Anaesthesiology, Clinic for Anaesthesiology and Intensive Care Medicine, Jena University Hospital (UKJ)
2019 Certification of intensive care medicine in the field of anaesthesiology
2017 - 2020 Senior consultant /interim head of the Divison of Anaesthesiology , Clinic for Anaesthesiology and Intensive Care Medicine (Director: Prof. M. Bauer), UKJ (
Since 2017 Representative for qualification and education at the Clinic for Anaesthesiology and Intensive Care Medicine, UKJ, Organisation of postgraduate continuing medical education
Since 2014 Senior consultant, Clinic for Anaesthesiology and Intensive Care Medicine, UKJ (Director: Prof. K. Reinhart)
2010 - 2014 Senior Registrar/Scientific Associate, Clinic for Anesthesiology and Intensive Care, Hannover Medical School (MHH)
2010 General Medical Council, Certificate of Full Registration as Medical Practitioner with Specialist Registration
2010 Specialist Certification in Anesthesiology, Germany
2008 Specialist Certification in Emergency Medicine, Germany
2005 - 2010 Residency, Department of Anesthesiology and Intensive Care, MHH (Directors: Prof. S. Piepenbrock/Prof. W. Koppert)
2005 License for Medical Practice (Approbation)


Scientific career

Since 07/2021 PI, Collaborative Research Centre (SFB) PolyTarget (projects A02 and T01) (
Since 09/2020 University Professor at the Medical Faculty of the Friedrich Schiller University Jena
2020 Offer and acceptance of W2-professorship "Clinical Anaesthesiology and Translational Intensive Care Medicine", Medical Faculty of the Friedrich-Schiller-University Jena
2019 Offer and declination of W2-Professorship „Operative lntensive Medicine", Department of Medicine of the Philipps-University Marburg
Since 11/2016 Head of the junior research group Translational Septomics at the ZIK Septomics ( with additional project funding by DFG and BMBF
Since 2015 PI, Research Group 1738 (DFG) (
Since 2015 PI, Center for Sepsis Control & Care (Integrated Research and Treatment Centers, BMBF) (
Since 2014 Junior Principal Investigator, Interdisciplinary Centre for Clinical Research (IZKF), University Hospital Jena (UKJ)
2013 Doctor of Philosophy (PhD), University of London, UK "Novel therapeutic strategies to reduce multiple organ dysfunction in experimental sepsis"
2010 - 2013 Fellow of the German Research Foundation and PhD student, Centre for Translational Medicine & Therapeutics (Head: Prof. C. Thiemermann),The William Harvey Research Institute, Queen Mary University of London, Barts & The London School of Medicine and Dentistry, UK
2005 Medical Doctor (MD) “The influence of the rpoS gene on the stress resistance of enterohemorrhagic Escherichia coli” (summa cum laude – passed with distinction)
2002 - 2005 MD student, Institute for Medical Microbiology and Hospital Epidemiology (Directors: Prof. D. Bitter-Suermann / Prof. S. Suerbaum), Hanover Medical School (MHH)


Positions, prizes and awards


Since 2020 (Co-)Editor of the journal intensive care medicine up2date (Georg Thieme Verlag)
Since 2020 Member of the expert panel of the journal AINS (Georg Thieme Verlag)
Since 2017 Member of the Editorial Board of "Shock" and „Frontiers in Immunology“
Since 2016 Member of the Board of ZIK Septomics
2016 - 2018 Member of te Board of the Center for Sepsis Control & Care (CSCC)
Since 2014 Auditor of the European Shock Society


Prizes and awards

2019      Research Prize of the Charlotte Lehmann Foundation
2015 DGAI Research Fellowship of the Fresenius Foundation 2015
2014 Hanseatic Doctoral Prize for experimental research in intensive and emergency medicine, Bremen
2013 Günther Schlag Memorial Award of the European Shock Society, Vienna
2012 DGAI Prize in the competition "Free Lectures" of the 14th Capital Congress of the DGAI for Anaesthesiology and Intensive Care Therapy, Berlin
2012 New Investigator Travel Award of the American Shock Society, Florida
2005 Promotional Prize of the Society of Friends of the MHH for the summer semester 2005

Selected publications

Chung HY, Wickel J, Hahn N, Mein N, Schwarzbrunn M, Koch P, Ceanga M, Haselmann H, Baade-Büttner C, von Stackelberg N, Hempel N, Schmidl L, Groth M, Andreas N, Götze J, Coldewey SM, Bauer M, Mawrin C, Dargvainiene J, Leypoldt F, Steinke S, Wang ZQ, Hust M, Geis C (2023) Microglia mediate neurocognitive deficits by eliminating C1q-tagged synapses in sepsis-associated encephalopathy. Sci Adv. 9(21):eabq7806. doi: 10.1126/sciadv.abq7806.

Kröller S, Wissuwa B, Dennhardt S, Krieg N, Thiemermann C, Daniel C, Amann K, Gunzer F, Coldewey SM (2023) Bruton's tyrosine kinase inhibition attenuates disease progression by reducing renal immune cell invasion in mice with hemolytic-uremic syndrome. Front Immunol. 14:1105181. doi: 10.3389/fimmu.2023.1105181. eCollection 2023.

Pirschel W, Mestekemper AN, Wissuwa B, Krieg N, Kröller S, Daniel C, Gunzer F, Tolosano E, Bauer M, Amann K, Heinemann SH, Coldewey SM (2022) Divergent roles of haptoglobin and hemopexin deficiency for disease progression of Shiga-toxin-induced hemolytic-uremic syndrome in mice. Kidney Int. 101(6):1171-1185. doi: 10.1016/j.kint.2021.12.024.

Dennhardt S, Pirschel W, Wissuwa B, Imhof D, Daniel C, Kielstein JT, Hennig-Pauka I, Amann K, Gunzer F, Coldewey SM (2022) Targeting the innate repair receptor axis via erythropoietin or pyroglutamate helix B surface peptide attenuates hemolytic-uremic syndrome in mice. Front Immunol. 13:1010882. doi: 10.3389/fimmu.2022.1010882. eCollection 2022.

Coldewey SM, Neu C, Baumbach P, Scherag A, Goebel B, Ludewig K, Bloos F, Bauer M (2020) Identification of cardiovascular and molecular prognostic factors for the medium-term and long-term outcomes of sepsis (ICROS): protocol for a prospective monocentric cohort study. BMJ Open 10:e036527. doi: 10.1136/bmjopen-2019-036527