Principle investigator

Dr. med. Sina Coldewey, PhD

Dr. med. Sina Coldewey, PhD


Phone: +49 3641 9-396500, 9-323101/11

Fax: +49 3641 9-323102


Curriculum vitae

Scientific career

Since 2016 Head of the junior research group Translational Septomics at the ZIK Septomics
Since 2015 Principal Investigator (PI), Research Group 1738 (DFG) (
Since 2015 PI, Center for Sepsis Control & Care (Integrated Research and Treatment Centers, BMBF) (
Since 2014 Junior PI, Interdisciplinary Centre for Clinical Research (IZKF), University Hospital Jena (UKJ)
2013 Doctor of Philosophy (PhD), University of London, UK "Novel therapeutic strategies to reduce multiple organ dysfunction in experimental sepsis"
2010 - 2013 Fellow of the German Research Foundation and PhD student, Centre for Translational Medicine & Therapeutics (Head: Prof. C. Thiemermann),The William Harvey Research Institute, Queen Mary University of London, Barts & The London School of Medicine and Dentistry, UK
2005 Medical Doctor (MD) “The influence of the rpoS gene on the stress resistance of enterohemorrhagic Escherichia coli” (summa cum laude – passed with distinction)
2002 - 2005 MD student, Institute for Medical Microbiology and Hospital Epidemiology (Directors: Prof. D. Bitter-Suermann / Prof. S. Suerbaum), Hanover Medical University (MHH)


Medical career

Since 2017 Interim Head of the Division of Anesthesiology, Department of Anesthesiology and Intensive Care (KAI), UKJ (
Since 2014 Consultant, KAI, UKJ (Directors: Prof. K. Reinhart/Prof. M. Bauer)
2010 - 2014 Senior Registrar/Scientific Associate, Department of Anesthesiology and Intensive Care, MHH
2010 Specialist Certification in Anesthesiology, Germany
2008 Specialist Certification in Emergency Medicine, Germany
2005 - 2010 Residency, Department of Anesthesiology and Intensive Care, MHH (Directors: Prof. S. Piepenbrock/Prof. W. Koppert)
2005 License for Medical Practice (Approbation)


Positions, prizes and awards


Since 2020 (Co-)Editor of the journal intensive care medicine up2date (Georg Thieme Verlag)
Since 2020 Member of the expert panel of the journal AINS (Georg Thieme Verlag)
Since 2017 Member of the Editorial Board of "Shock" and „Frontiers in Immunology“
Since 2014 Auditor of the European Shock Society


Prizes and awards

2019      Research Prize of the Charlotte Lehmann Foundation
2015 DGAI Research Fellowship of the Fresenius Foundation 2015
2014 Hanseatic Doctoral Prize for experimental research in intensive and emergency medicine, Bremen
2013 Günther Schlag Memorial Award of the European Shock Society, Vienna
2012 DGAI Prize in the competition "Free Lectures" of the 14th Capital Congress of the DGAI for Anaesthesiology and Intensive Care Therapy, Berlin
2012 New Investigator Travel Award of the American Shock Society, Florida
2005 Promotional Prize of the Society of Friends of the MHH for the summer semester 2005

Selected publications

Dennhardt S, Pirschel W, Wissuwa B, Daniel C, Gunzer F, Lindig S, Medyukhina A, Kiehntopf M, Rudolph WW, Zipfel PF, Gunzer M, Figge MT, Amann K, Coldewey SM. Modeling Hemolytic-Uremic Syndrome: In-Depth Characterization of Distinct Murine Models Reflecting Different Features of Human Disease. Front Immunol. 2018, 9:Article 1459, doi: 10.3389/fimmu.2018.01459.

Wissuwa B, Heinemann SH, Bauer M, Coldewey SM. Studies into Slo1 K+ channels and their ligand docosahexaenoic acid in murine sepsis to delineate off-target effects of immunonutrition. Life Sci. 2018, 203:112-120, doi: 10.1016/j.lfs.2018.04.031.

Coldewey SM, Benetti E, Collino M, Pfeilschifter J, Sponholz C, Bauer M, Huwiler A, Thiemermann C. Elevation of serum sphingosine-1-phosphate attenuates impaired cardiac function in experimental sepsis. Sci Rep. 2016, 6:27594. doi: 10.1038/srep27594.

Gobbetti T, Coldewey SM, Chen J, McArthur S, le Faouder P, Cenac N, Flower RJ, Thiemermann C, Perretti M. Nonredundant protective properties of FPR2/ALX in polymicrobial murine sepsis. Proc Natl Acad Sci U S A. 2014, 111(52):18685-90. doi: 10.1073/pnas.1410938111.

Coldewey SM, Rogazzo M, Collino M, Patel NS, Thiemermann C. Inhibition of IκB kinase reduces the multiple organ dysfunction caused by sepsis in the mouse. Dis Model Mech. 2013, 6:1031-42. doi: 10.1242/dmm.012435.