Publications

2021

von Loeffelholz C, Coldewey SM, Birkenfeld AL (2021) A Narrative Review on the Role of AMPK on De Novo Lipogenesis in Non-Alcoholic Fatty Liver Disease: Evidence from Human Studies. Cells 10(7), 1822; https://www.mdpi.com/2073-4409/10/7/1822, Paper

Mohammad S, Al Zoubi S, Collotta D, Krieg N, Wissuwa B, Ferreira Alves G, Purvis GSD, Norata GD, Baragetti A, Catapano AL, Solito E, Zechendorf E, Schürholz T, Correa W, Brandenburg K, Coldewey SM, Collino M, Yaqoob MM, Martin L, Thiemermann C (2021) A synthetic peptide designed to neutralize lipopolysaccharides attenuates metaflammation and diet-induced metabolic derangement in mice. Front Immunol., doi.org/10.3389/fimmu.2021.701275, Paper

Press AT, Babic P, Hoffmann B, Müller T, Foo W, Hauswald W, Benecke J, Beretta M, Cseresnyés Z, Hoeppener S,
Nischang I, Coldewey SM, Gräler MH, Bauer R, Gonnert F, Gaßler N, Wetzker R, Figge MT, Schubert US, Bauer M (2021) Targeted delivery of a phosphoinositide 3-kinase inhibitor to restore organ function in sepsis. EMBO Molecular Medicine, accepted.

Chung HY, Neu C, Wickel J, Kuckertz SL, Coldewey SM (2021) Neurofilament light chain in patients with COVID-19 and bacterial pneumonia. Ann Neurol. 90(1):174-175. doi: 10.1002/ana.26135, Letter

König R, Kolte A, Ahlers O, Oswald M, Krauss V, Roell D, Sommerfeld O, Dimopoulos G, Tsangaris I, Antoniadou E, Jaishankar N, Bogatsch H, Löffler M, Rödel M, Garcia-Moreno M, Tuchscherr L, Sprung CL, Singer M, Brunkhorst F, Oppert M, Gerlach H, Claus RA, Coldewey SM, Briegel J, Giamarellos-Bourboulis EJ, Keh D, Bauer M (2021) Use of IFNγ/IL10 Ratio for Stratification of Hydrocortisone Therapy in Patients With Septic Shock. Front Immunol. 12:607217, doi: 10.3389/fimmu.2021.607217, Paper

2020

Baumbach P, Schmidt-Winter C, Hoefer J, Derlien S, Best N, Herbsleb M, Coldewey SM (2020) A Pilot Study on the Association of Mitochondrial Oxygen Metabolism and Gas Exchange during Cardiopulmonary Exercise Testing: Is there a Mitochondrial Threshold? Front. Med. 7:585462. doi: 10.3389/fmed.2020.585462, Paper

O'Riordan CE, Purvis GSD, Collotta D, Wissuwa B, Sheikh MH, Ferreira Alves G, Krieg N, Mohammad S, Callender LA, Coldewey SM, Collino M, Greaves DR, Thiemermann C (2020) X-linked immunodeficient mice with no functional Bruton's Tyrosine Kinase are protected from sepsis-induced multiple organ failure. Front. Immunol. 11:581758, Paper

Nicklas JY, Diener O, Leistenschneider M, Sellhorn C, Schön G, Winkler M, Daum G, Schwedhelm E, Schröder J, Fisch M, Schmalfeldt B, Izbicki JR, Bauer M, Coldewey SM, Reuter DA, Saugel B (2020) Personalised haemodynamic management targeting baseline cardiac index in high-risk patients undergoing major abdominal surgery: a randomised single-centre clinical Trial. Br. J. Anaesth. 125(2):122-132, Paper

Stallmach A, Kortgen A, Gonnert F, Coldewey SM, Reuken P, Bauer M (2020) Infliximab against severe COVID-19-induced cytokine storm syndrome with organ failure-a cautionary case series. Crit Care. 24(1):444, Paper

Gläser A, Hammerl F, Gräler MH, Coldewey SM, Völkner C, Frech MJ, Yang F, Luo J, Tönnies E, von Bohlen und Halbach O, Brandt N, Heimes D, Neßlauer A-M, Korenke GC, Owczarek-Lipska M, Neidhardt J, Rolfs A, Wree A, Witt M, Bräuer AU (2020) Identification of Brain-Specific Treatment Effects in NPC1 Disease by Focusing on Cellular and Molecular Changes of Sphingosine-1-Phosphate Metabolism. Int. J. Mol. Sci. 21, 4502; Paper

Coldewey SMNeu C, Baumbach P, Scherag A, Goebel B, Ludewig K, Bloos F, Bauer M (2020) Identification of cardiovascular and molecular prognostic factors for the medium-term and long-term outcomes of sepsis (ICROS): protocol for a prospective monocentric cohort study. BMJ Open 10:e036527, Paper

Neu CLange AIWissuwa BColdewey SM (2020) Mikrozirkulationsstörung in der Sepsis. DIVI 2020; 11: 66–73, DOI 10.3238/DIVI.2020.0066-0073

Sobbe IV, Krieg N, Dennhardt S, Coldewey SM (2020) Involvement of NF-κB1 and the Non-Canonical NF-κB Signaling Pathway in the Pathogenesis of Acute Kidney Injury in Shiga-Toxin-2-Induced Hemolytic-Uremic Syndrome in Mice. Shock, 10.1097/SHK.0000000000001558, [Online ahead of print] Paper

Neu C, Baumbach P, Plooij AK, Skitek K, Götze J, von Loeffelholz C, Schmidt-Winter C, Coldewey SM (2020) Non-Invasive Assessment of Mitochondrial Oxygen Metabolism in the Critically Ill Patient Using the Protoporphyrin IX‐Triplet State Lifetime Technique – a Feasibility Study. Front. Immunol. 11:757, Paper

Zechendorf E, O'Riordan CE, Stiehler L, Wischmeyer N, Chiazza F, Collotta D, Denecke B, Ernst S, Müller-Newen G, Coldewey SM, Wissuwa B, Collino M, Simon TP, Schuerholz T, Stoppe C, Marx G, Thiemermann C, Martin L (2020) Ribonuclease 1 attenuates septic cardiomyopathy and cardiac apoptosis in a murine model of polymicrobial sepsis. JCI Insight 5(8):e131571, Paper

Stepanovska B, Lange AI, Schwalm S, Pfeilschifter J, Coldewey SM, Huwiler A (2020) Downregulation of S1P lyase improves barrier function in human cerebral microvascular endothelial cells following an inflammatory challenge. Int. J. Mol. Sci. 21(4), 1240; Paper

Sponholz C, Schuwirth C, Koenig L, Hoyer H, Coldewey SM, Schelenz C, Doenst T, Kortgen A, Bauer M (2020) Intraoperative reduction of vasopressors using processed electroencephalographic monitoring in patients undergoing elective cardiac surgery: a randomized clinical trial. J Clin Monit Comput. 34(1):71-80. Paper 

2019

O'Riordan CE, Purvis GSD, Collotta D, Chiazza F, Wissuwa B, Al Zoubi S, Stiehler L, Martin L, Coldewey SM, Collino M, Thiemermann C (2019) Bruton's Tyrosine Kinase Inhibition Attenuates the Cardiac Dysfunction Caused by Cecal Ligation and Puncture in Mice. Front. Immunol. 10:2129, Paper

Dennhardt S, Finke KR, Huwiler A, Coldewey SM (2019) Sphingosine-1-phosphate promotes barrier-stabilizing effects in human microvascular endothelial cells via AMPK-dependent mechanisms. Biochimica et Biophysica Acta (BBA) - Molecular Basis of Disease 1865(4):774-781, Paper

Baumbach P, Neu C, Derlien S, Bauer M, Nisser M, Buder A, Coldewey SM (2019) A pilot study of exercise-induced changes in mitochondrial oxygen metabolism measured by a cellular oxygen metabolism monitor (PICOMET). Biochim Biophys Acta Mol Basis Dis. 1865(4):749-758, Paper

2018

Bauer M, Coldewey SM, Leitner M, Löffler B, Weis S, Wetzker R (2018) Deterioration of Organ Function as a Hallmark in Sepsis: The Cellular Perspective. Front Immunol. 9:1460, Paper

Dennhardt S, Pirschel W, Wissuwa B, Daniel C, Gunzer F, Lindig S, Medyukhina A, Kiehntopf M, Rudolph WW, Zipfel PF, Gunzer M, Figge MT, Amann K, Coldewey SM (2018) Modeling Hemolytic-Uremic Syndrome: In-Depth Characterization of Distinct Murine Models Reflecting Different Features of Human Disease. Front Immunol. 9, Article 1459, Paper

Wissuwa B, Heinemann SH, Bauer M, Coldewey SM (2018) Studies into Slo1 K+ channels and their ligand docosahexaenoic acid in murine sepsis to delineate off-target effects of immunonutrition. Life Sci. 203:112-120, Paper

Meinel C, Spartà G, Dahse HM, Hörhold F, König R, Westermann M, Coldewey SM, Cseresnyés Z, Figge MT, Hammerschmidt S, Skerka C, Zipfel PF (2018) Streptococcus pneumoniae From Patients With Hemolytic Uremic Syndrome Binds Human Plasminogen via the Surface Protein PspC and Uses Plasmin to Damage Human Endothelial Cells. J Infect Dis. 217(3):358-370, Paper

2017

Weis S, Dickmann P, Pletz MW, Coldewey SM, Gerlach H, Bauer M (2017) Eine neue Definition führt zu neuen Konzepten. Dtsch Arztebl. 29-30: A1424-A1428, A6-A7.

Wöchtl B, Gunzer F, Gerner W, Gasse H, Koch M, Bagó Z, Ganter M, Weissenböck H, Dinhopl N, Coldewey SM, von Altrock A, Waldmann KH, Saalmüller A, Zimmermann K, Steinmann J, Kehrmann J, Klein-Hitpass L, Blom J, Ehricht R, Engelmann I, Hennig-Pauka I (2017) Comparison of clinical and immunological findings in gnotobiotic piglets infected with Escherichia coli O104:H4 outbreak strain and EHEC O157:H7. Gut Pathog. 9:30, Paper

Dickmann P, Scherag A, Coldewey SM, Sponholz C, Brunkhorst FM, Bauer M (2017) [Epistemology in the intensive care unit-what is the purpose of a definition? : Paradigm shift in sepsis research]. Der Anaesthesist 66:622–625 Paper

Seidel RA, Claudel T, Schleser FA, Ojha NK, Westerhausen M, Nietzsche S, Sponholz C, Cuperus F, Coldewey SM, Heinemann SH, Pohnert G, Trauner M, Bauer M (2017) Impact of higher-order heme degradation products on hepatic function and hemodynamics. J Hepatol., pii: S0168-8278(17)30208-8. Paper

Previously

Coldewey SM, Benetti E, Collino M, Pfeilschifter J, Sponholz C, Bauer M, Huwiler A, Thiemermann C (2016) Elevation of serum sphingosine-1-phosphate attenuates impaired cardiac function in experimental sepsis. Sci. Rep. 6:27594, doi: 10.1038/srep27594.

Gobbetti T, Coldewey SM, Chen J, McArthur S, le Faouder P, Cenac N, Flower RJ, Thiemermann C, Perretti M (2014) Nonredundant protective properties of FPR2/ALX in polymicrobial murine sepsis. Proc. Natl. Acad. Sci. U S A 111(52):18685-90, doi: 10.1073/pnas.1410938111.

Coldewey SM, Thiemermann C (2014) Pleiotropic effects of atorvastatin in experimental sepsis: preservation of β1-adrenoreceptor signaling in the heart. Shock. 41(5):458-9, doi: 10.1097/SHK.0000000000000154. No abstract available.

Chen J, Chiazza F, Collino M, Patel NS, Coldewey SM, Thiemermann C (2014) Gender dimorphism of the cardiac dysfunction in murine sepsis: signalling mechanisms and age-dependency. PLoS One. 9(6):e100631, doi: 10.1371/journal.pone.0100631.

Coldewey SM, Rogazzo M, Collino M, Patel NS, Thiemermann C (2013) Inhibition of IκB kinase reduces the multiple organ dysfunction caused by sepsis in the mouse. Dis. Model. Mech. 6(4):1031-42, doi: 10.1242/dmm.012435.

Coldewey SM, Khan AI, Kapoor A, Collino M, Rogazzo M, Brines M, Cerami A, Hall P, Sheaff M, Kieswich JE, Yaqoob MM, Patel NS, Thiemermann C (2013) Erythropoietin attenuates acute kidney dysfunction in murine experimental sepsis by activation of the β-common receptor. Kidney Int. 84(3):482-90, doi: 10.1038/ki.2013.118.

Khan AI, Coldewey SM, Patel NS, Rogazzo M, Collino M, Yaqoob MM, Radermacher P, Kapoor A, Thiemermann C (2013) Erythropoietin attenuates cardiac dysfunction in experimental sepsis in mice via activation of the β-common receptor. Dis. Model. Mech. 6(4):1021-30, doi: 10.1242/dmm.011908.

Jüttner B, Kröplin J, Coldewey SM, Witt L, Osthaus WA, Weilbach C, Scheinichen D (2008) Unsaturated long-chain fatty acids induce the respiratory burst of human neutrophils and monocytes in whole blood. Nutr. Metab. (Lond). 5:19, doi: 10.1186/1743-7075-5-19.

Kieckbusch H, Coldewey SM, Hollenhorst J, Haeseler G, Hillemanns P, Hertel H (2008) Patent blue sentinel node mapping in cervical cancer patients may lead to decreased pulse oximeter readings and positive methaemoglobin results. Eur. J. Anaesthesiol. 25(5):365-8, doi: 10.1017/S0265021508003578.

Coldewey SM, Hartmann M, Schmidt DS, Engelking U, Ukena SN, Gunzer F (2007) Impact of the rpoS genotype for acid resistance patterns of pathogenic and probiotic Escherichia coli. BMC Microbiol. 7:21.

Ukena SN, Westendorf AM, Hansen W, Rohde M, Geffers R, Coldewey S, Suerbaum S, Buer J, Gunzer F (2005) The host response to the probiotic Escherichia coli strain Nissle 1917: specific up-regulation of the proinflammatory chemokine MCP-1. BMC Med Genet. 6:43.