Host Septomics

The main scientific interest of the Host Septomics Research Group for Infection and Microbiome Research is to contribute to an understanding of the complex interactions between human pulmonary mucosa and the environment in health and disease. A particular focus is on cellular pathways and networks of C-type lectin and CEACAM-receptors. Further besides bacteria we also focus on fungi as commensals and potential pulmonary pathogens of the human lung. We understand that in pulmonary inflammation the human host, together with its associated lung microbiome must be regarded as a functional unit. Disease mechanisms can, therefore, only be described when taking both sides of this “metaorganism” into account. For our questions, we also develop novel tools and techniques using 16s rDNA and ITS sequencing to understand regulatory events and cellular/bacterial and cellular/fungeal response profiles in model systems of chronic inflammatory diseases.

Prof. Slevogt,leader of the group, is a member of several large-scale consortia delineating the pathophysiology of human infectious diseases.


Prof. Dr. med. Hortense Slevogt, DTM & H

Prof. Dr. med. Hortense Slevogt, DTM & H



Patil ND, Domingues O, Masquelier C, Theresine M, Schlienger O, Njinju Amin Asaba C, Thomas M, Seguin-Devaux C, Slevogt H, Ollert M, Zimmer J (2022) Imprint of Initial Education and Loss of Ly49C/I in Activated Natural Killer Cells of TAP1-KO and C57BL/6 Wildtype Mice. Front Immunol. 13:818015, doi: 10.3389/fimmu.2022.818015. eCollection 2022,

Cammann C, Israel N, Slevogt H, Seifert U (2022) Recycling and Reshaping-E3 Ligases and DUBs in the Initiation of T Cell Receptor-Mediated Signaling and Response. Int J Mol Sci. 23(7):3424, doi: 10.3390/ijms23073424,

Slevogt H, Brauer M (2022) Rescue therapy for refractory status asthmaticus with updosed omalizumab adjusted for IgE level, body weight and effect. Respir Med Case Rep. 36:101614. doi: 10.1016/j.rmcr.2022.101614,

Klassert TE, Zubiria-Barrera C, Neubert R, Stock M, Schneegans A, López M, Driesch D, Zakonsky G, Gastmeier P, Slevogt H, Leistner R (2022) Comparative analysis of surface sanitization protocols on the bacterial community structures in the hospital environment. Clin Microbiol Infect. S1198-743X(22)00109-4,

Klaile E, Prada Salcedo JP, Klassert TE, Besemer M, Bothe AK, Durotin A, Müller MM, Schmitt V, Luther CH, Dittrich M, Singer BB, Dandekar T, Slevogt H (2021) Antibody ligation of CEACAM1, CEACAM3, and CEACAM6, differentially enhance the cytokine release of human neutrophils in responses to Candida albicans. Cell. Immunol. 372,


Busch K, Kny M, Huang N, Klassert TE, Stock M, Hahn A, Graeger S, Todiras M, Schmidt S, Chamling B, Willenbrock M, Groß S, Biedenweg D, Heuser A, Scheidereit C, Butter C, Felix SB, Otto O, Luft FC, Slevogt H, Fielitz J (2021) Inhibition of the NLRP3/IL-1β axis protects against sepsis-induced cardiomyopathy. J Cachexia Sarcopenia Muscle Actions, doi: 10.1002/jcsm.12763.    

Böttcher K, Braunschmidt K, Hirth G, Schärich K, Klassert TE, Stock M, Sorgatz J, Fischer-Burkart S, Ullrich S, Frankenberger S, Kritsch D, Kosan C, Küppers R, Strobl LJ, Slevogt H, Zimber-Strobl U, Jungnickel B (2021) Context-dependent regulation of immunoglobulin mutagenesis by p53. Mol Immunol. 138:128-136, doi: 10.1016/j.molimm.2021.08.005

Klassert TE, Leistner R, Zubiria-Barrera C, Stock M, López M, Neubert R, Driesch D, Gastmeier P, Slevogt H (2021) Bacterial colonization dynamics and antibiotic resistance gene dissemination in the hospital environment after first patient occupancy: a longitudinal metagenetic study. Microbiome 9(1):169, doi: 10.1186/s40168-021-01109-7

Mirhakkak MH, Schäuble S, Klassert TE, Brunke S, Brandt P, Loos D, Uribe RV, Senne de Oliveira Lino F, Ni Y, Vylkova S, Slevogt H, Hube B, Weiss GJ, Sommer MOA, Panagiotou G (2021) Metabolic modeling predicts specific gut bacteria as key determinants for Candida albicans colonization levels. ISME J. 5(5):1257-1270, doi: 10.1038/s41396-020-00848-z

Thada S, Horvath GL, Müller MM, Dittrich N, Conrad ML, Sur S, Hussain A, Pelka K, Gaddam SL, Latz E, Slevogt H, Schumann RR, Burkert S (2021) Interaction of TLR4 and TLR8 in the Innate Immune Response against Mycobacterium tuberculosis. Int J Mol Sci. 22(4):1560. doi: 10.3390/ijms22041560

Vella G, Ritzmann F, Wolf L, Kamyschnikov A, Stodden H, Herr C, Slevogt H, Bals R, Beisswenger C (2021) IL-17C contributes to NTHi-induced inflammation and lung damage in experimental COPD and is present in sputum during acute exacerbations. PLoS One 16(1):e0243484. doi: 10.1371/journal.pone.0243484. eCollection 2021 


Mirhakkak MH, Schäuble S, Klassert TE, Brunke S, Brandt P, Loos D, Uribe RV, Senne de Oliveira Lino F, Ni Y, Vylkova S, Slevogt H, Hube B, Weiss GJ, Sommer MOA, Panagiotou G (2020) Metabolic modeling predicts specific gut bacteria as key determinants for Candida albicans colonization levels. ISME J., doi: 10.1038/s41396-020-00848-z. Online ahead of print.

Cho SX, Rudloff I, Lao JC, Pang MA, Goldberg R, Bui CB, McLean CA, Stock M, Klassert TE, Slevogt H, Mangan NE, Cheng W, Fischer D, Gfroerer S, Sandhu MK, Ngo D, Bujotzek A, Lariviere L, Schumacher F, Tiefenthaler G, Beker F, Collins C, Kamlin COF, König K, Malhotra A, Tan K, Theda C, Veldman A, Ellisdon AM, Whisstock JC, Berger PJ, Nold-Petry CA, Nold MF (2020) Characterization of the pathoimmunology of necrotizing enterocolitis reveals novel therapeutic opportunities. Nat Commun. 11(1):5794. doi: 10.1038/s41467-020-19400-w.

Machata S, Müller MM, Lehmann R, Sieber P, Panagiotou G, Carvalho A, Cunha C, Lagrou K, Maertens J, Slevogt H, Jacobsen ID (2020) Proteome analysis of bronchoalveolar lavage fluids reveals host and fungal proteins highly expressed during invasive pulmonary aspergillosis in mice and humans. Virulence 11(1):1337-1351. doi: 10.1080/21505594.2020.1824960.

Zubiría-Barrera C, Stock M, Neubert R, Vester A, Kulle A, Schneegans A, Leistner R, Gastmeier P, Slevogt H, Klassert TE (2020) A simple sequence-based filtering method for the removal of contaminants in low-biomass 16S rRNA amplicon sequencing approaches. J Microbiol MethodsActions;106060. doi: 10.1016/j.mimet.2020.106060. Online ahead of print.

Riebold D, Lubig J, Wolf P, Wolf C, Russow K, Loebermann M, Slevogt H, Mohr E, Feldhusen F, Reisinger EC (2020) First molecular detection of Pneumocystis spp. in red foxes (Vulpes vulpeslinnaeus, 1758) and raccoon dogs (Nyctereutes procyonoidesgray, 1834). Comp. Immunol. Microbiol. Infect. Dis. 14;73:101531. doi: 10.1016/j.cimid.2020.101531. Online ahead of print. 

Hassan MIA, Kruse JM, Krüger T, Dahse HM, Cseresnyés Z, Blango MG, Slevogt H, Hörhold F, Ast V, König R, Figge MT, Kniemeyer O, Brakhage AA, Voigt K (2020) Functional surface proteomic profiling reveals the host heat-shock protein A8 as a mediator of Lichtheimia corymbifera recognition by murine alveolar macrophages. Environ Microbiol.. doi: 10.1111/1462-2920.15140. Online ahead of print.        

Riebold D, Russow K, Schlegel M, Wollny T, Thiel J, Freise J, Hüppop O, Eccard JA, Plenge-Bönig A, Loebermann M, Ulrich RG, Klammt S, Mettenleiter TC, Reisinger EC (2020) Occurrence of Gastrointestinal Parasites in Small Mammals from Germany. Vector Borne Zoonotic Dis. 20(2):125-133. doi: 10.1089/vbz.2019.2457. Epub 2019 Sep 12.       

Thada S, Burkert S, Sivangala R, Hussain A, Sur S, Dittrich N, Conrad ML, Slevogt H, Latha Gaddam S, Schumann RR (2020) A SNP upstream of the cyclic GMP-AMP synthase (cGAS) gene protects from relapse and extra-pulmonary TB and relates to BCG vaccination status in an Indian cohort. Genes Immun. 21(1):13-26, doi: 10.1038/s41435-019-0080-1. Epub 2019 May 23.

Klassert TEZubiria-Barrera CKankel SStock MNeubert R, Lorenzo-Diaz F, Doehring N, Driesch D, Fischer D, Slevogt H (2020) Early bacterial colonization and antibiotic resistance gene acquisition in newborns. Front Cell Infect Microbiol. 10:332. doi: 10.3389/fcimb.2020.00332.

Draenert R, Jung N; Choosing Wisely (Klug entscheiden) DGI Working Group. (2020) Update on the "Choosing Wisely" initiative in infectious diseases in Germany. Infection 48(3):317-321, doi: 10.1007/s15010-020-01400-z. [Epub ahead of print] Review.


Klaile E, Müller MM, Zubiría-Barrera C, Brehme S, Klassert TE, Stock M, Durotin A, Nguyen TD, Feer S, Singer BB, Zipfel PF, Rudolphi S, Jacobsen ID, Slevogt H (2019) Unaltered Fungal Burden and Lethality in Human CEACAM1-Transgenic Mice During Candida albicans Dissemination and Systemic Infection. Front Microbiol. 10:2703, doi: 10.3389/fmicb.2019.02703. eCollection 2019.

Dimitriou V, Biehl L, Hamprecht A, Vogel W, Dörfel D, Peter S, Schafhausen P, Rohde H, von Lilienfeld-Toal M, Klassert T, Slickers P, Ehricht R, Slevogt H, Christ H, Hellmich M, Farowski F, Tsakmaklis A, Higgins P, Seifert H, Vehreschild M (2019) Controlling intestinal colonization of high-risk haematology patients with ESBL-producing Enterobacteriaceae: a randomized, placebo-controlled, multicentre, Phase II trial (CLEAR). J Antimicrob Chemother.74(7):2065-2074, 

Töpfer N, Müller MM, Dahms M, Ramoji A, Popp J, Slevogt H, Neugebauer U (2019) Raman spectroscopy reveals LPS-induced changes of biomolecular composition in monocytic THP-1 cells in a label-free manner. Integr Biol (Camb)., doi: 10.1093/intbio/zyz009.

Becker A, Vella G, Galata V, Rentz K, Beisswenger C, Herr C, Walter J, Tierling S, Slevogt H, Keller A, Bals R (2019) The composition of the pulmonary microbiota in sarcoidosis - an observational study. Respir Res. 20(1):46. doi: 10.1186/s12931-019-1013-2.


Fischer K, Doehn JM, Herr C, Lachner C, Heinrich A, Kershaw O, Voss M, Jacobson MH, Gruber AD, Clauss M, Witzenrath M, Bals R, Gutbier B, Slevogt H (2018) Acute Moraxella catarrhalis Airway Infection of Chronically Smoke-Exposed Mice Increases Mechanisms of Emphysema Development: A Pilot Study. Eur J Microbiol Immunol (Bp). 8(4):128-134. doi: 10.1556/1886.2018.00019.

Kroegel C, Foerster M, Quickert S, Slevogt H, Neumann T (2018) Vasculitides and eosinophilic pulmonary diseases. Z Rheumatol., doi: 10.1007/s00393-018-0561-z. [Epub ahead of print] German.

Kroegel C, Foerster M, Quickert S, Slevogt H, Neumann T (2018) Vasculitides and eosinophilic pulmonary diseases. Internist (Berl)., doi: 10.1007/s00108-018-0479-1. Review. German. 

Lehmann R, Schmidt A, Pastuschek J, Müller MM, Fritzsche A, Dieterle S, Greb RR, Markert UR, Slevogt H (2018) Comparison of sample preparation techniques and data analysis for the LC-MS/MS-based identification of proteins in human follicular fluid. Am J Reprod Immunol., e12994. doi: 10.1111/aji.12994. [Epub ahead of print]

Goyal S, Castrillón-Betancur JC, Klaile E, Slevogt H (2018) The Interaction of Human Pathogenic Fungi With C-Type Lectin Receptors. Front Immunol. 9:1261, doi: 10.3389/fimmu.2018.01261. Review

Klassert TE, Goyal S, Stock M, Driesch D, Hussain A, Berrocal-Almanza LC, Myakala R, Sumanlatha G, Valluri V, Ahmed N, Schumann RR, Flores C, Slevogt H (2018) AmpliSeq Screening of Genes Encoding the C-Type Lectin Receptors and Their Signaling Components Reveals a Common Variant in MASP1 Associated with Pulmonary Tuberculosis in an Indian Population. Front Immunol. 9:242. doi: 10.3389/fimmu.2018.00242

Dietert K, Nouailles G, Gutbier B, Reppe K, Berger S, Jiang X, Schauer AE, Hocke AC, Herold S, Slevogt H, Witzenrath M, Suttorp N, Gruber AD (2018) Digital Image Analyses on Whole Lung Slides in Mouse Models of Acute Pneumonia. Am J Respir Cell Mol Biol. 58(4):440-448, doi: 10.1165/rcmb.2017-0337MA.

Lehmann R, Müller MM, Klassert TE, Driesch D, Stock M, Heinrich A, Conrad T, Moore C, Schier UK, Guthke R, Slevogt H (2018) Differential regulation of the transcriptomic and secretomic landscape of sensor and effector functions of human airway epithelial cells. Mucosal Immunol. 11(3):627-642, doi: 10.1038/mi.2017.100.

Marx C, Marx-Blümel L, Lindig N, Thierbach R, Hoelzer D, Becker S, Wittig S, Lehmann R, Slevogt H, Heinzel T, Wang ZQ, Beck JF, Sonnemann J (2018) The sirtuin 1/2 inhibitor tenovin-1 induces a nonlinear apoptosis-inducing factor-dependent cell death in a p53 null Ewing's sarcoma cell line. Invest New Drugs 36(3):396-406, doi: 10.1007/s10637-017-0541-1. [Epub ahead of print]


Leonor Fernandes Saraiva JP, Zubiria-Barrera C, Klassert TE, Lautenbach MJ, Blaess M, Claus RA, Slevogt H, König R (2017) Combination of Classifiers Identifies Fungal-Specific Activation of Lysosome Genes in Human Monocytes. Front Microbiol. 8:2366. doi: 10.3389/fmicb.2017.02366. eCollection 2017.

Irmscher S, Döring N, Halder LD, Jo EAH, Kopka I, Dunker C, Jacobsen ID, Luo S, Slevogt H, Lorkowski S, Beyersdorf N, Zipfel PF, Skerka C (2017) Kallikrein Cleaves C3 and Activates Complement. J Innate Immun., doi: 10.1159/000484257. [Epub ahead of print]

Dietert K, Gutbier B, Wienhold SM, Reppe K, Jiang X, Yao L, Chaput C, Naujoks J, Brack M, Kupke A, Peteranderl C, Becker S, von Lachner C, Baal N, Slevogt H, Hocke AC, Witzenrath M, Opitz B, Herold S, Hackstein H, Sander LE, Suttorp N, Gruber AD (2017) Spectrum of pathogen- and model-specific histopathologies in mouse models of acute pneumonia. PLoS One. 12(11):e0188251. doi: 10.1371/journal.pone.0188251. eCollection 2017.

Saraiva JP, Oswald M, Biering A, Röll D, Assmann C, Klassert T, Blaess M, Czakai K, Claus R, Löffler J, Slevogt H, König R (2017) Fungal biomarker discovery by integration of classifiers. BMC Genomics. 18(1):601. doi: 10.1186/s12864-017-4006-x.

Schauer AE, Klassert TE, von Lachner C, Riebold D, Schneeweiß A, Stock M, Müller MM, Hammerschmidt S, Bufler P, Seifert U, Dietert K, Dinarello CA, Nold MF, Gruber AD, Nold-Petry CA, Slevogt H (2017) IL-37 Causes Excessive Inflammation and Tissue Damage in Murine Pneumococcal Pneumonia. J Innate Immun. 9(4):403-418. doi: 10.1159/000469661.

Müller MM, Lehmann R, Klassert TE, Reifenstein S, Conrad T, Moore C, Kuhn A, Behnert A, Guthke R, Driesch D, Slevogt H (2017) Global analysis of glycoproteins identifies markers of endotoxin tolerant monocytes and GPR84 as a modulator of TNFα expression. Sci Rep. 7: 838.

Klaile E, Müller MM, Schäfer MR, Clauder AK, Feer S, Heyl KA, Stock M, Klassert TE, Zipfel PF, Singer BB, Slevogt H (2017) Binding of Candida albicans to Human CEACAM1 and CEACAM6 Modulates the Inflammatory Response of Intestinal Epithelial Cells. MBio 8(2). pii: e02142-16. doi: 10.1128/mBio.02142-16. 

Huang N, Kny M, Riediger F, Busch K, Schmidt S, Luft FC, Slevogt H, Fielitz J (2017) Deletion of Nlrp3 protects from inflammation-induced skeletal muscle atrophy. Intensive Care Med Exp 5(1):3. doi: 10.1186/s40635-016-0115-0.

Riege K, Hölzer M, Klassert TE, Barth E, Bräuer J, Collatz M, Hufsky F, Mostajo N, Stock M, Vogel B, Slevogt H, Marz M (2017) Massive Effect on LncRNAs in Human Monocytes During Fungal and Bacterial Infections and in Response to Vitamins A and D. Sci Rep 7:40598. doi: 10.1038/srep40598.

Klassert TE, Bräuer J, Hölzer M, Stock M, Riege K, Zubiría-Barrera C, Müller MM, Rummler S, Skerka C, Marz M, Slevogt H (2017) Differential Effects of Vitamins A and D on the Transcriptional Landscape of Human Monocytes during Infection. Sci Rep 7:40599. doi: 10.1038/srep40599.

Tominski D, Katchanov J, Driesch D, Daley MB, Liedtke A, Schneider A, Slevogt H, Arastéh K, Stocker H (2017) The late-presenting HIV-infected patient 30 years after the introduction of HIV testing: spectrum of opportunistic diseases and missed opportunities for early diagnosis. HIV Med 18(2):125-132. doi: 10.1111/hiv.12403.


Goyal S, Klassert TE, Slevogt H (2016) C-type lectin receptors in tuberculosis: what we know. Med Microbiol Immunol 205(6):513-535. Review.

Scherag A, Schöneweck F, Kesselmeier M, Taudien S, Platzer M, Felder M, Sponholz C, Rautanen A, Hill AV, Hinds CJ, Hossain H, Suttorp N, Kurzai O, Slevogt H, Giamarellos-Bourboulis EJ, Armaganidis A, Trips E, Scholz M, Brunkhorst FM (2016) Genetic Factors of the Disease Course after Sepsis: A Genome-Wide Study for 28Day Mortality. EBioMedicine 12:239-246. doi: 10.1016/j.ebiom.2016.08.043.

Heinrich A, Heyl KA, Klaile E, Müller MM, Klassert TE, Wiessner A, Fischer K, Schumann RR, Seifert U, Riesbeck K, Moter A, Singer BB, Bachmann S, Slevogt H (2016) Moraxella catarrhalis induces CEACAM3-Syk-CARD9-dependent activation of human granulocytes. Cell Microbiol 18(11):1570-1582. doi: 10.1111/cmi.12597.

Javaheri A, Kruse T, Moonens K, Mejías-Luque R, Debraekeleer A, Asche CI, Tegtmeyer N, Kalali B, Bach NC, Sieber SA, Hill DJ, Königer V, Hauck CR, Moskalenko R, Haas R, Busch DH, Klaile E, Slevogt H, Schmidt A, Backert S, Remaut H, Singer BB, Gerhard M (2016) Helicobacter pylori adhesin HopQ engages in a virulence-enhancing interaction with human CEACAMs. Nat Microbiol. 2:16189. doi: 10.1038/nmicrobiol.2016.189. Erratum: Nat Microbiol 2016 Nov 7;2:16243. doi: 10.1038/nmicrobiol.2016.243. 

Heyl KA, Karsten CM, Slevogt H (2016) Galectin-3 binds highly galactosylated IgG1 and is crucial for the IgG1 complex mediated inhibition of C5aReceptor induced immune responses. Biochem Biophys Res Commun 479(1):86-90. doi: 10.1016/j.bbrc.2016.09.038.

Berrocal-Almanza LC, Goyal S, Hussain A, Klassert TE, Driesch D, Grozdanovic Z, Sumanlatha G, Ahmed N, Valluri V, Conrad ML, Dittrich N, Schumann RR, Lala B, Slevogt H (2016) S100A12 is up-regulated in pulmonary tuberculosis and predicts the extent of alveolar infiltration on chest radiography: an observational study. Sci Rep 6:31798. doi: 10.1038/srep31798.

Manchanda H, Seidel N, Blaess MF, Claus RA, Linde J, Slevogt H, Sauerbrei A, Guthke R, Schmidtke M (2016) Differential Biphasic Transcriptional Host Response Associated with Coevolution of Hemagglutinin Quasispecies of Influenza A Virus. Front Microbiol 7:1167. doi: 10.3389/fmicb.2016.01167.

Heinrich A, Haarmann H, Zahradnik S, Frenzel K, Schreiber F, Klassert TE, Heyl KA, Endres AS, Schmidtke M, Hofmann J, Slevogt H (2016) Moraxella catarrhalis decreases antiviral innate immune responses by down-regulation of TLR3 via inhibition of p53 in human bronchial epithelial cells. FASEB J 30(6):2426-34. doi: 10.1096/fj.201500172R.

Katchanov J, Wöstmann K, Tominski D, Jefferys L, Liedtke A, Schneider A, Slevogt H, Arastéh K, Stocker H (2016) Burden and spectrum of infectious disease in Germany 2009-2014: a multicentre study from Berlin's Municipal Hospitals. Infection 44(2):187-95. doi: 10.1007/s15010-015-0834-2.


Haarmann H, Steiner T, Schreiber F, Heinrich A, Zweigner J, N'Guessan PD, Slevogt H (2015) The role and regulation of Moraxella catarrhalis-induced human beta-defensin 3 expression in human pulmonary epithelial cells. Biochem Biophys Res Commun 467(1):46-52. doi: 10.1016/j.bbrc.2015.09.126.

Grozdanovic Z, Berrocal Almanza LC, Goyal S, Hussain A, Klassert TE, Driesch D, Tokaryeva V, Löschmann YY, Sumanlatha G, Ahmed N, Valluri V, Schumann RR, Lala B, Slevogt H (2015) A Novel Reading Scheme for Assessing the Extent of Radiographic Abnormalities and Its Association with Disease Severity in Sputum Smear-Positive Tuberculosis: An Observational Study in Hyderabad/India. PLoS One 10(9):e0138070. doi: 10.1371/journal.pone.0138070.

Acosta-Herrera M, Lorenzo-Diaz F, Pino-Yanes M, Corrales A, Valladares F, Klassert TE, Valladares B, Slevogt H, Ma SF, Villar J, Flores C (2015) Lung Transcriptomics during Protective Ventilatory Support in Sepsis-Induced Acute Lung Injury. PLoS One. 10(7):e0132296. doi: 10.1371/journal.pone.0132296. Erratum in: PLoS One 10(12):e0145696.

Gutbier B, Fischer K, Doehn JM, von Lachner C, Herr C, Klaile E, Frischmann U, Singer BB, Riesbeck K, Zimmermann W, Suttorp N, Bachmann S, Bals R, Witzenrath M, Slevogt H (2015) Moraxella catarrhalis induces an immune response in the murine lung that is independent of human CEACAM5 expression and long-term smoke exposure. Am J Physiol Lung Cell Mol Physiol 309(3):L250-61. doi: 10.1152/ajplung.00265.2014.

Dittrich N, Berrocal-Almanza LC, Thada S, Goyal S, Slevogt H, Sumanlatha G, Hussain A, Sur S, Burkert S, Oh DY, Valluri V, Schumann RR, Conrad ML (2015) Toll-like receptor 1 variations influence susceptibility and immune response to Mycobacterium tuberculosis. Tuberculosis (Edinb) 95(3):328-35. doi: 10.1016/

Katchanov J, Jefferys L, Tominski D, Wöstmann K, Slevogt H, Arastéh K, Stocker H (2015) Cryptococcosis in HIV-infected hospitalized patients in Germany: Evidence for routine antigen testing. J Infect 71(1):110-6. doi: 10.1016/j.jinf.2015.01.011.

Walther E, Richter M, Xu Z, Kramer C, von Grafenstein S, Kirchmair J, Grienke U, Rollinger JM, Liedl KR, Slevogt H, Sauerbrei A, Saluz HP, Pfister W, Schmidtke M (2015) Antipneumococcal activity of neuraminidase inhibiting artocarpin. Int J Med Microbiol 305(3):289-97. doi: 10.1016/j.ijmm.2014.12.004.


Heyl KA, Klassert TE, Heinrich A, Müller MM, Klaile E, Dienemann H, Grünewald C, Bals R, Singer BB, Slevogt H (2014) Dectin-1 is expressed in human lung and mediates the proinflammatory immune response to nontypeable Haemophilus influenzae. MBio 5(5):e01492-14. doi: 10.1128/mBio.01492-14.

Klassert TE, Hanisch A, Bräuer J, Klaile E, Heyl KA, Mansour MK, Tam JM, Vyas JM, Slevogt H (2014) Modulatory role of vitamin A on the Candida albicans-induced immune response in human monocytes. Med Microbiol Immunol 203(6):415-24. doi: 10.1007/s00430-014-0351-4. Erratum: Med Microbiol Immunol 203(6):425. Mansour, Michael M [corrected to Mansour, Michael K]. 

N'Guessan PD, Haarmann H, Steiner T, Heyl K, Schreiber F, Heinrich A, Slevogt H (2014) The Moraxella catarrhalis-induced pro-inflammatory immune response is enhanced by the activation of the epidermal growth factor receptor in human pulmonary epithelial cells. Biochem Biophys Res Commun 450(2):1038-44. doi: 0.1016/j.bbrc.2014.06.102.

Singer BB, Opp L, Heinrich A, Schreiber F, Binding-Liermann R, Berrocal-Almanza LC, Heyl KA, Müller MM, Weimann A, Zweigner J, Slevogt H (2014) Soluble CEACAM8 interacts with CEACAM1 inhibiting TLR2-triggered immune responses. PLoS One 17;9(4):e94106. doi: 10.1371/journal.pone.0094106.


Klaile E, Klassert TE, Scheffrahn I, Müller MM, Heinrich A, Heyl KA, Dienemann H, Grünewald C, Bals R, Singer BB, Slevogt H (2013) Carcinoembryonic antigen (CEA)-related cell adhesion molecules are co-expressed in the human lung and their expression can be modulated in bronchial epithelial cells by non-typable Haemophilus influenzae, Moraxella catarrhalis, TLR3, and type I and II interferons. Respir Res 14:85. doi: 10.1186/1465-9921-14-85.

Weimann A, Rieger A, Zimmermann M, Gross M, Hoffmann P, Slevogt H, Morawietz L (2010) Comparison of six immunohistochemical markers for the histologic diagnosis of neoplasia in Barrett's esophagus. Virchows Arch. 457(5):537-45. doi: 10.1007/s00428-010-0972-y .

Weimann A, Zimmermann M, Gross M, Slevogt H, Rieger A, Morawietz L (2010) CDX2 and LI-cadherin expression in esophageal mucosa: use of both markers can facilitate the histologic diagnosis of Barrett's esophagus and carcinoma. Int J Surg Pathol. 18(5):330-7. doi: 10.1177/1066896910364228 .

Singer BB, Scheffrahn I, Kammerer R, Suttorp N, Ergun S, Slevogt H (2010) Deregulation of the CEACAM expression pattern causes undifferentiated cell growth in human lung adenocarcinoma cells. PLoS One. 5(1):e8747. doi: 10.1371/journal.pone.0008747.

Meixenberger K, Pache F, Eitel J, Schmeck B, Hippenstiel S, Slevogt H, N'Guessan P, Witzenrath M, Netea MG, Chakraborty T, Suttorp N, Opitz B (2010) Listeria monocytogenes-infected human peripheral blood mononuclear cells produce IL-1beta, depending on listeriolysin O and NLRP3. J Immunol. 184(2):922-30. doi: 10.4049/jimmunol.0901346.

Vardarova K, Scharf S, Lang F, Schmeck B, Opitz B, Eitel J, Hocke AC, Slevogt H, Flieger A, Hippenstiel S, Suttorp N, N'guessan PD (2009) PKC(alpha) and PKC(epsilon) differentially regulate Legionella pneumophila-induced GM-CSF. Eur Respir J. 34(5):1171-9. doi: 10.1183/09031936.00171908 .

Dje N'Guessan P, Riediger F, Vardarova K, Scharf S, Eitel J, Opitz B, Slevogt H, Weichert W, Hocke AC, Schmeck B, Suttorp N, Hippenstiel S (2009). Statins control oxidized LDL-mediated histone modifications and gene expression in cultured human endothelial cells. Arterioscler Thromb Vasc Biol. 29(3):380-6. doi: 10.1161/ATVBAHA.108.178319.

Slevogt H, Zabel S, Opitz B, Hocke A, Eitel J, N'guessan PD, Lucka L, Riesbeck K, Zimmermann W, Zweigner J, Temmesfeld-Wollbrueck B, Suttorp N, Singer BB (2008) CEACAM1 inhibits Toll-like receptor 2-triggered antibacterial responses of human pulmonary epithelial cells. Nat Immunol. 9(11):1270-8. doi: 10.1038/ni.1661.

Lippmann J, Rothenburg S, Deigendesch N, Eitel J, Meixenberger K, van Laak V, Slevogt H, N'guessan PD, Hippenstiel S, Chakraborty T, Flieger A, Suttorp N, Opitz B (2008) IFNbeta responses induced by intracellular bacteria or cytosolic DNA in different human cells do not require ZBP1 (DLM-1/DAI). Cell Microbiol. 10(12):2579-88. doi: 10.1111/j.1462-5822.2008.01232.x.

Eitel J, Krüll M, Hocke AC, N'Guessan PD, Zahlten J, Schmeck B, Slevogt H, Hippenstiel S, Suttorp N, Opitz B (2008) Beta-PIX and Rac1 GTPase mediate trafficking and negative regulation of NOD2. J Immunol. 181(4):2664-71.

Schmeck B, Lorenz J, N'guessan PD, Opitz B, van Laak V, Zahlten J, Slevogt H, Witzenrath M, Flieger A, Suttorp N, Hippenstiel S (2008) Histone acetylation and flagellin are essential for Legionella pneumophila-induced cytokine Expression. J Immunol. 181(2):940-7.

Vinzing M, Eitel J, Lippmann J, Hocke AC, Zahlten J, Slevogt H, N'guessan PD, Günther S, Schmeck B, Hippenstiel S, Flieger A, Suttorp N, Opitz B (2008) NAIP and Ipaf control Legionella pneumophila replication in human cells. J Immunol. 180(10):6808-15.

Slevogt H, Maqami L, Vardarowa K, Beermann W, Hocke AC, Eitel J, Schmeck B, Weimann A, Opitz B, Hippenstiel S, Suttorp N, N'Guessan PD (2008) Differential regulation of Moraxella catarrhalis-induced interleukin-8 response by protein kinase C isoforms. Eur Respir J. 31(4):725-35. doi: 10.1183/09031936.00103507.

N'Guessan PD, Temmesfeld-Wollbrück B, Zahlten J, Eitel J, Zabel S, Schmeck B, Opitz B, Hippenstiel S, Suttorp N, Slevogt H (2007) Moraxella catarrhalis induces ERK- and NF-kappaB-dependent COX-2 and prostaglandin E2 in lung Epithelium. Eur Respir J. 30(3):443-51.

N'Guessan PD, Vigelahn M, Bachmann S, Zabel S, Opitz B, Schmeck B, Hippenstiel S, Zweigner J, Riesbeck K, Singer BB, Suttorp N, Slevogt H (2007) The UspA1 protein of Moraxella catarrhalis induces CEACAM-1-dependent apoptosis in alveolar epithelial cells. J Infect Dis. 195(11):1651-60.

Slevogt H, Seybold J, Tiwari KN, Hocke AC, Jonatat C, Dietel S, Hippenstiel S, Singer BB, Bachmann S, Suttorp N, Opitz B (2007) Moraxella catarrhalis is internalized in respiratory epithelial cells by a trigger-like mechanism and initiates a TLR2- and partly NOD1-dependent inflammatory immune Response. Cell Microbiol. 9(3):694-707.

Opitz B, Vinzing M, van Laak V, Schmeck B, Heine G, Günther S, Preissner R, Slevogt H, N'Guessan PD, Eitel J, Goldmann T, Flieger A, Suttorp N, Hippenstiel S (2006) Legionella pneumophila induces IFNbeta in lung epithelial cells via IPS-1 and IRF3, which also control bacterial replication. J Biol Chem. 281(47):36173-9.

Slevogt H, Schmeck B, Jonatat C, Zahlten J, Beermann W, van Laak V, Opitz B, Dietel S, N'Guessan PD, Hippenstiel S, Suttorp N, Seybold J (2006) Moraxella catarrhalis induces inflammatory response of bronchial epithelial cells via MAPK and NF-kappaB activation and histone deacetylase activity reduction. Am J Physiol Lung Cell Mol Physiol. 290(5):L818-26.

Slevogt H, Tiwari KN, Schmeck B, Hocke A, Opitz B, Suttorp N, Seybold J (2006) Adhesion of Moraxella catarrhalis to human bronchial epithelium characterized by a novel fluorescence-based Assay. Med Microbiol Immunol. 95(2):73-83

Rosseau S, Wiechmann K, Moderer S, Selhorst J, Mayer K, Krüll M, Hocke A, Slevogt H, Seeger W, Suttorp N, Seybold J, Lohmeyer J (2005) Moraxella catarrhalis--infected alveolar epithelium induced monocyte recruitment and oxidative burst. Am J Respir Cell Mol Biol. 32(2):157-66.

Slevogt H, Tintelnot K, Seybold J, Suttorp N (2004) Lymphadenopathy in a pregnant woman from Brazil. Lancet. 363(9417):1282.

Höflich C, Sabat R, Rosseau S, Temmesfeld B, Slevogt H, Döcke WD, Grütz G, Meisel C, Halle E, Göbel UB, Volk HD, Suttorp N (2004) Naturally occurring anti-IFN-gamma autoantibody and severe infections with Mycobacterium cheloneae and Burkholderia cocovenenans. Blood 103(2):673-5 .

Slevogt H, Grobusch MP, Suttorp N (2003) Gnathostomiasis without eosinophilia led to a 5-year delay in diagnosis. J Travel Med. 10(3):196 .

Grobusch MP, Bollmann R, Schönberg A, Slevogt H, Garcia V, Teichmann D, Jelinek T, Flick H, Bergmann F, Rosseau S, Temmesfeld-Wollbrück B, Suttorp N (2003) Leptospirosis in travelers returning from the Dominican Republic. J Travel Med. 10(1):55-8 .

Slevogt H, Schiller R, Wesselmann H, Suttorp N (2001) Ascending cellulitis after an insect bite. Lancet 357(9258):768.