In addition to studies on “classical” sepsis, the junior research group also carries out paradigmatic studies on a microcirculation disorder that is crucial for the impairment of organ functions. The hemolytic-uraemic syndrome (HUS), which can occur as a systemic complication of infections with enterohemorrhagic Escherichia coli (EHEC), provides fundamental insights into the pathogenesis of the microcirculation disorder with microthrombosis which is crucial for septic shock.
Clinically, HUS is defined as acute renal failure and microangiopathic hemolytic anemia occurring with thrombocytopenia.
The group investigates the molecular mechanisms of HUS by means of various in vitro and in vivo model systems. The aim is
- to develop and evaluate suitable in vitro and in vivo model systems for HUS
- to analyze the influence of heme and heme degradation products on acute renal failure in Stx-induced HUS (www.hhdp.uni-jena.de/index.php/acute-kidney-injury )
- to develop pharmacological intervention strategies to improve acute renal failure and to improve morbidity and mortality in HUS